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Pharm Test 4 :( > Antianginals And Erectile Dysfunction > Flashcards

Antianginals And Erectile Dysfunction Flashcards

0
Q

Calcium channel blockers

A

Nifedipine - dihyropyridines
Verapamil and diltiazem -heart rate lowering

Block inward flow of Ca
Vasodilators -decrease after load
Coronary a. Vasospasm
Prophylaxis against angina attacks

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1
Q

Nitroglycerin

A

Metabolized to NO in VSM
VSM relaxation - primarily venous dilation -> reducing preload

No survival benefit
Tolerance with continuous use
Interacts with other Vasodilators and alcohol

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2
Q

Nifedipine

A

Ca channel blocker

Only affects VSM in vasculature

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3
Q

Verapamil diltiazem

A

Ca channel blockers
Heart rate lowering
Act on vasculature and SA and AV nodal tissue

Diltiazem better tolerated

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4
Q

Propranolol

A

Beta blocker
Lowers HR, contractile force, and systemic BP
Reduces mortality

Initial agent in pts w/ CAD who present with stable angina

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5
Q

Sildenafil

A

Competitive inhibition of PDE-5 (expressed highly in smooth mm. Of corpora cavernosum)

Prolongs activity of NO/cGMP

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Pharm Test 4 :( (6 decks)

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