Antihistaminics and Decongestants Flashcards
What is the number 1 site of ocular allergy?
conjunctiva (can also be lids and lashes)
What is innate immunity?
(<12 hours) non-specific acute response (first-line) that lacks immunological memory
what are the key cells associated with innate immunity?
humoral and cell mediated: killer T cells and macrophages
What is adaptive immunity?
(1-2 weeks) occurs after prior exposure to an antigen and has specificity and memory
what are the key cells associated with the adaptive immune response?
humoral and cell mediated: memory B and T cells
what is an antigen?
a foreign/endogenous substance having the capacity to evoke an immunological response
what is hypersensitivity or an allergic reaction?
exaggerated immune responses to an innate or foreign innocuous antigen = allergen (environmental, biological, chemical based)
what are the 2 types of hypersensitivity responses that are most commonly associated with ocular reactions?
types 1 and 4
what is a type 1 hypersensitivity reaction?
IgE based (only one) - activation of mast cells or basophils (allergy)
what are 3 examples of a type 1 response?
atopy, asthma, anaphylaxis
what is a type 2 hypersensitivity reaction?
(antibody mediated or cytotoxic) non-systemic/local IgM or IgG based attack = local inflammation
what are 3 examples of a type 2 response?
graves disease, myasthenia gravis or autoimmune diseases
what is a type 3 hypersensitivity reaction?
(immune complex) circulating or systemic IgM or IgG based immune complexes (originate in circulation but can land locally)
what are 4 examples of a type 3 response?
arthritis, nephritis, vasculitis, lupus
what is a type 4 hypersensitivity reaction?
(delayed type CD4 and/or cell-mediated CD8) T-cell based reactions that lead to macrophage activation and/or cell lysis = inflammation
what are some examples of a type 4 response?
IDDM, MS, RA, contact dermatitis, conjunctivitis medicamentosa
how quickly does a type 1 hypersensitivity reaction occur?
5-30 min
what are the 5 steps of a type 1 hypersensitivity reaction?
- B-cell + antigen
- B-cell + IgE synthesis
- Mast cell/basophil + surface IgE
- Mast cell/basophil + Ag = Ca++ entry
- Degranulation = histamine release
what cell is local - mast cells or basophils?
mast cells are local (at tissue) and basophils are in blood circulating
what 2 things does Ca++ trigger when it enters a mast cell/basophil?
triggers phospholipase A2 and mast cell degranulation = histamine (pre-formed)
what is phospholipase A2 involved in?
inflammatory cascade
how long does it take for a type 4 response?
2-3 days for development (much faster than adaptive immune response)
what triggers a type 4 response?
re-exposure (memory) response = TB testing, MS, chronic transplant rejection
How is type 4 different than types 1-3?
T-cell based (unlike 1-3) and antibody independent
Does a type 4 response use histamine?
no - cytokines are released upon antigen re-exposure and activate macrophages = phagocytic and lytic enzymes
when might you use an antihistamine with a steroid?
if symptoms include itch and other significant ocular allergy signs (redness, chemosis, eyelid edema) –> involves inflammation (PGs) as well as mast cells
Is itch always a sign of ocular allergy?
no - mast cells can degranulate by scratching and histamine is released
what are 5 allergy therapies?
decongestants, antihistamines, mast cell stabilizers, NSAIDS, steroids
would you advise patients with ocular allergies to use a warm or cold compress?
cold compress - constriction of vessels = less redness and leakage (swelling)
what are 4 adrenergic agonists used for decongestants?
phenylephrine, naphazoline, oxymeazoline, tetrahydrozoline
what are the actions of decongestants?
vasoconstriction - reduces hyperemia and edema (palliative therapy)
How can decongestants differentially diagnose episcleritis?
if the decongestant blanches the conjunctiva (makes it white) - the redness was superficial and was episcleritis vs. scleritis