Antihistamines And Autocoids Flashcards
Diphenhydramine
Antihistamine
Inhibits H1 receptors
Treat allergic reactions, motion sickness, doxorubicin reactions
Anticholinergic effects; paradoxical excitement in cats
Crosses BBB
Famotidine
H2 blocker
H2 antagonist
Decreases GI acid production
Crosses BBB but less than H1 antagonists
Fluoxetine
SSRI
Inhibits reuptake of serotonin
OCD aggression, separation anxiety
Vomiting, diarrhea, anorexia, restlessnss
Crosses BBB
Cyproheptadine
Antihistamine
Inhibits H1 receptors and non specific serotonin receptor antagonist
Allergic reactions and stimulate appetite in cats
Anticholinergic effetcs; sedation
Crosses BBB
Trazodone
Antidepressant
5HT2a antagonist, weak ssri
Treat anxiety
Sedation, adverse GI effects
Yes
Selegiline
Serotonergic agent
Monoamine oxidase B inhibitor
Canine or feline cognitive disorder
Vomiting, diarrhea, anorexia, restlessness
Crosses BBB
Meclizine
Antihistamine
Inhibits H1 receptors, anticholinergic activity
Antihistamine with antiemetic and sedative effects; treats vestibular disease
Sedation
Crosses BBB
Autocoids
Substances derived from various cell types that exert effects on other cell types within the same region
Classes of autocoids
Amines- histamine
Eicosanoids
Peptide autacoids
Histamine receptors
HR1 acts on Gq
HR2 acts on Gs
HR3 and HR4 act on Gi
How does histamine affect the following tissues:
Heart, respiration, GI, Blood vessels, nervous system, skin
Increases heart rate and contration
Smooth muscle contraction
Gastric acid secretion
Vasodilation
Stimulation of nociceptors, arousal, reddening, wheal, flare
Serotonin receptors
5HT2 works on Gq
5HT4, 5HT6, 5HT7 works on Gs
5HT1, 5HT5 works on Gi
5HT3 works on sodium and calcium channels
How does serotonin affect the following tissues:
GI
Blood vessels
Nervous system
Leukocytes
Increase motility
Vasodilation, vasoconstriction
Regulate mood and memory
Activates leukocytes
