Anti-fungals Flashcards
Amphotericin B
Produced by?
Static or cidal?
Spectrum?
MOA?
Side effects?
Produced by streptomyces nodosus
Static or cidal based on concentration
Histoplasma, blastomyces, cryptococcus, coccidioides, candida, rhodotorula, mucor
Binds to egosterol and increases permeability of cells
Nephrotoxicity
Itraconazole
Compare with keto
Cidal or static
MOA
More potent than keto
Cidal or static based on concentration
Blocks conversion of ianosterol to ergosterol; P450
Fluconazole
How is it in cats
Compare to other azoles
Spectrum
Well tolerated in cats
Broad spectrum
Better CNS and ocular distribution than itraconazole
Safest liver wise
Same MOA as other azoles
Ketoconazole
Static or cidal?
Spectrum?
Side effects?
Static or cidal based on concentration
Broad spectrum except feline sporothrix
Nausea, vomiting, anorexia, diarrhea, hepatophaty, alopecia, abortigenous
Same MOA as itra and fluco
Griseofluvin
Produced by?
Static or cidal?
Spectrum?
MOA?
Side effects?
Produced by penicillum griseofulvum
Fungistatic
Dermatophytes
Inhibits mitosis and synthesis of nucleic acids and proteins. Also breaks down membranes
Vomiting/diarrhea, teratogenic, hepatotoxic, myelosuppression, phototoxicity
Terbinafine
Static or cidal
Spectrum
MOA
Fungicidal
Superficial mycoses- better for dermatophytes than grise and keto
Inhibits squalene epoxidase; no interaction with P450
Iodides
Used for sporothrix and in horses
Unknown MOA
Iodism- nausea, vomiting, diarrhea, twitching, hypothermia, scaling and alopecia
