Antihistamine ritter

Question 1

Which cells store histamine?

Answer 1

Mast cells
Basophils
ECL cells
Histaminergic CNS neurons

Question 2

H1 and H2 MOA in the cell?

Answer 2

H1 activates IP3 production and Ca++ and activates NfkB

H2 activates adenyl cyclase for cAMP production

Question 3

Effect of H1 on…

Lungs
Vascular smooth muscle
Vascular endothelium
Peripheral nerves

Answer 3

Lungs - bronchoconstriction
Vascular smooth muscle - vasodilation
Vascular endothelium - shrinkage and separation
Peripheral nerves - Depolarization of sensory afferent nerves

Question 4

What are some adverse effects of H1 antihistamines?

Answer 4

Anticholinergic effects
Orthostatic hypotension
Sedation

Question 5

Name the three drugs classified as ethanolamine

Answer 5

Diphenhydramine
Dimenhydrinate
Doxylamine

Question 6

Name an ethylenediamine

Answer 6

Pyrilamine

Question 7

Brompheniramine is classified as which class of drug?

Answer 7

Alkylamine

Question 8

Meclizine and hydroxyzine are classified as which class of drug?

Answer 8

Piperazines

Question 9

Promethazine is classified as which class of drug?

Answer 9

Phenothiazines