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Pharm II > Antihistamine drugs > Flashcards

Antihistamine drugs Flashcards

1
Q

Potency of Levocetirizine, fexofenadine, desloratidine

A

Potency: D>Levo>F

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2
Q

Hydroxyzine PAMoate

A

1st gen H1 blocker

  • insomnia, anxiety (crosses BBB better)

A for anxiety

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3
Q

Cyclizine

A

1st gen. H1 blocker

  • motion sickness, vertigo
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4
Q

Brompheniramine

A

1st gen H1 blocker

  • Allergies
  • Moderatly sedating
  • Often found in combination with “cold” products
  • avoid in elders
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5
Q

Azelastine

A

2nd gen. H1 blocker

  • Dual MOA
    • mast cell stabilizer and H1 blocker
  • application to cause may cause nose bleed but less systemtic side effects
    • formulation=nasal spray
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6
Q

Fexofenadine

A

2nd gen. H1 blocker

  • highest safety profile (no cyp metabolism)
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7
Q

Nizatidine

A

H2 blocker

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8
Q

Ranitidine

A

H2 blocker

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9
Q

Cimetidine

A

H2 blocker

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10
Q

Chlorpheniramine

A

1st gen H1 blocker

  • Allergies
  • Moderatly sedating
  • Often found in combination with “cold” products
  • avoid in elders
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11
Q

Famotidine

A

H2 blocker

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12
Q

Cyproheptadine

A

1st gen. H1 blocker

  • weight gain due to 5-HT2 blockade
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13
Q

Doxylamine

A

1st gen. H1 blocker

  • Used for: Insomnia & allergies
  • Highly sedating
  • large doses= QTc prolongation
  • Avoid in elders
    • ​strong anticholinergic effects
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14
Q

Meclizine

A

1st gen. H1 blocker

Motion sickness vertigo

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15
Q

Hydroxyzine HCL

A

1st gen H1 blocker

  • Allergies, urticaria
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16
Q

Olopatidine

A

2nd gen. H1 blocker

  • Dual MOA
    • mast cell stabilizer and H1 blocker
  • application to cause may cause nose bleed but less systemtic side effects
    • formulation=nasal spray
17
Q

Levocetirizine

A

2nd gen. H1 blocker

18
Q

Epinephrine

A

histamine antagonist

  • relaxes smooth muscles
  • stimulates alpha and beta receptors
19
Q

Diphenhydramine

A

1st gen. H1 blocker

  • Used for: Insomnia & allergies
  • Highly sedating
  • large doses= QTc prolongation
  • Avoid in elders
    • ​strong anticholinergic effects
20
Q

Cromolyn sodium

A

histamine antagonist

  • works over several weeks
  • stabilizes mast cells to prevent degranulation
  • used as adjunct for pts. with severe allergies or allergic asthma
21
Q

Desloratidine

A

2nd gen. H1 blocker

Least likely to cause sleepyness

22
Q

Loratidine

A

2nd gen. H1 blocker

  • Many CYP DDI’s
23
Q

Promethazine

A

1st gen. H1 blocker

  • Anti-emetic (E for anti-Emetic)
  • highly sedating
  • alpha blockade→hypotension
  • D2 blockade→dystonic rxn’s, akathisia (inability to sit still)
  • Strong anti-cholinergic effects
24
Q

Cetirizine

A

2nd gen. H1 blocker

  • causes the most sleepiness

Pharm II (12 decks)

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