Antihistamine

Question 1

what type of receptors will histamine bind

Answer 1

it binds to histamine receptors which are GPCRs

Question 2

what sort of compound is histamine

Answer 2

it is a biogenic amine

Question 3

what histamine receptors mediate the allergic response

Answer 3

the H1 receptors

Question 4

what effects are seen when histamine binds to the H1 receptor

Answer 4

releases NO to cause vasodilation and increased permeability, contracts the intestinal and bronchial smooth muscle walls, activates sensory nerve endings to cause itch and pain

Question 5

classic allergic response is a triple response of what three things

Answer 5

wheal - leakage of plasma from post capillary venules
flare - axon reflex release a vasodilator from sensory nerve endings
itch - sensitisation of sensory nerve endings.

Question 6

so antihistamine drugs do what

Answer 6

these antagonise the H1 receptors resulting in a lessened allergic response