Antigout

Question 1

1st Line Therapy for gout

Answer 1

NSAIDs

Question 2

Overall concern for gout medications

Answer 2

Serious adverse effects that damage kidney and liver function

Question 3

What is gout?

Answer 3

Over production or under secretion of uric acid that builds up in the tissue of joints.

Question 4

Mechanism of action of antigout drugs

Answer 4

targets the defect in uric acid production

Question 5

Indications of antigout drugs

Answer 5

For acute gout attacks or gouty arthritis

Question 6

Contraindications of antigout drugs

Answer 6

Hypersensitivity, severe renal, GI, hepatic, or cardiac disorders

Question 7

Adverse Effects for antigout drugs

Answer 7

anemia, severe skin conditions, GI bleeding

Question 8

Interactions for antigout drugs

Answer 8

Antibiotics, beta blockers

Question 9

Nursing Considerations for antigout drugs

Answer 9

Watch BUN, creatinine and liver function studies to determine whether liver and kidneys are functioning properly. Monitor uric acid levels- drug should make serum level go down. Antibiotics and beta blockers might need to be reduced

Question 10

Antigout Key drugs

Answer 10

Allopurinol

Colchicine

Question 11

Mechanism of Action and Indication for allopurinol

Answer 11

Inhibits xanthine oxidase, which helps to create uric acid, therefore it is effective for both acute and gouty arthritis. Used mostly for prevention of attacks.

Question 12

Allopurinol Adverse Effects

Answer 12

Severe! Anemia, skin conditions like Stevens-Johnson syndrome and toxic skin necrosis

Question 13

Mechanism of Action for Colchicine

Answer 13

Reduces inflammatory response to deposits of urate crystals in joint tissue, therefore it is more effective in treatment of acute gout attacks.

Question 14

Colchicine Adverse Effects

Answer 14

Monitor for renal, hepatic, and cardiac function. Watch liver and kidney labs, and monitor for GI/GU bleeding.