Antigen presentation Flashcards
the important antigen presenting cells
- dendritic cells
- macrophage/monocytes
- B lymphocytes
toll like receptors
-recognize PAMPS (pathogen associated molecular patterns)
what follows activation of TLR
- cytokine production
- IL-1 and TNF
functions of IL-1 and TNF
- increased adhesiveness of endothelial cells
- activation of the liver to release acute phase proteins such as C reactive protein. levels of CRP is a good indicator as to the activity of disease
- effect on the hypothalamus producing fever, depression, anorexia (sickness cytokines)
once TLR is activated, what does the APC do
-move to draining lymph nodes and interact with T cells
T cells will only recognize foreign antigens when…
-they are presented inside class 11 major histocompatibility antigens
T cells are activated when
-their T cell receptors interact with foreign peptide inside the groove of a class 2 MHC molecules
where in the chromosome is MHC located?
-short arm of chromosome 6
what is the most polymorphic system in biology
MHC
haplotype
- a set of genes on one chromosome
- therefore we get one haplotype from each parent
- two people with different haplotypes could bear children with 4 different combination s of haplotype, therefore if you have 5 children then one will definitely match
structure of MHC class 1 -where?
- 3 alpha subunits and one beta
- found on all cells except RBC
MHC class 2 structure -where?
- 2 alpha and 2 beta subunits
- found only on antigen presenting cells
similarities of MHC class 1 and 2
-both have a peptide binding cleft
clefts of MHC 1 and 2
MHC1: made up by 2 alpha units
MHC2: made up by 1 alpha and 1 beta
-ankylosing spondylitis
HLA B27
