Antigen Presentation Flashcards
what are the anchors and what are they useful for
the anchors are amino acids are the end of the peptides needed to make the peptide project outwards from the grooves pf the mhc class I molecule
how many chains do mhc class II to have and what are they
mhc class II has two alpha chains and two beta chains
how many amino acids does mhc class II like to present
10 - 30 amino acids
how many amino acids does mhc class I like to presnt
8-11 amino acids
are viral antigens preseneted in the endogenous or exogenous pathway
normally endogenous because cd8 cytotoxic t cells are needed to destroy the cell but rarely in some cases its both
what are natural killer cells
natural killer cells are t cells that do not detect antigens but they detect mhc molecules
what do natural killer cells do
natural killer cells destroy cells that have an absence of mhc
what is the structure of peptide that binds to mhc class II
the peptide has anchors throughout
what are some features of the mhc class II binding pockets
the binding pockets are more shallower less conserved and permissive
what does permissive mean in regards to the mhc class II binding pocket
permissive means that there are less bothered about presenting a specific time of peptide and are more open to present a range
what is the difference betweeen the anchor residue in mhc class I and mhc class II
mhc class I has a more deep binding pocket with the anchor residues binding ony at the start and at the end and the mhc clas II has the anchor residues binding throughout with binding pockets more shallower
is there a difference between human leukocyte antigen, major histo-compatibility complex
no, mhc is the overarching term but hla is found n humans
what happens when a new viral antigen enters the a population of specifc variant hla molecules
the population will struggle to present whatever the viral is
and put the population at risk
what is polymorphism in hla molecules
have different types of hla molecules increasing its gentetic variance within the population
what do all normal nucleated cells present on their surface
mhc class I
