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Cchm Lec > ANTIGEN > Flashcards

ANTIGEN Flashcards

1
Q

They are glycoproteins by nature

A

Immunoglobulin and antibodies

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2
Q

Found in serum portion of blood

A

Glycoproteins

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3
Q

Compositions:
Protein :
Carbohydrate:

A

Protein: 82-96%
Carbohydrates: 2-14%

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4
Q

Behavior of specific methods

A

Serum electrophoresis

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5
Q

Screening test of cc detects clinical disorder

A

Electrophoresis

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6
Q

Different factor of immunoglobulin

A

Cellulose acetate

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7
Q

It has recommended pH alkali

A

Cellulose acetate (pH 8.6)

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8
Q

Differentation of material

A

Citrate agar

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9
Q

Acidic pH are required

A

Citrate agar (pH 6-6.3)

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10
Q

Mnemonics of immunoglobulin

A

G - IgG
A - IgA
M - IgM
E -IgE
D - IgD

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11
Q

Normal serum electrophoresis patterns

A

Albumin
Alpha 1 globulin
Alpha 2 globulin
Beta globulin
Gamma globulin/ gamma region

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12
Q

Immunoglobulin play a role as _________

A

Antigen recognition

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13
Q

Immunoglobulin help in process/biological activity in _______________ and _____________

A

Opsonization and compliment activation

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14
Q

Interaction in specific antigen

A

Antigen recognition

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15
Q

act as Preparation for eating in phagocytosis

A

Opsonization

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16
Q

Compliment system types

A

Antigen dependent: classical pathway
Antigen independent: alternative and lytic pathway

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17
Q

Most abundant proteins

A

Albumin

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18
Q

Slowest protein

A

Gamma region/ gamma globulin

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19
Q

Region where immunoglobulin found

A

Gamma region/ gamma globulin

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20
Q

Effect on beta region

A

Beta gamma bridging

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21
Q

Condition in beta gamma bridging

A

Liver cirrhosis

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22
Q

Tall Spike pattern in gamma region (has elevated plasma protein)

A

Multiple myeloma

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23
Q

Protein found in multiple myeloma

A

Bence jones protein

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24
Q

Full discovery light chain of immunoglobulin in multiple myeloma

A

Bence jones protein

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25
Q

Bence jones protein
Temperature:
Dissolving temperature:

A

Temperature: 60 degree celsius
Dissolving temperature: 80 degrees Celsius

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26
Q

Corresponding proteins: alpha 1 globulin

A
  • Alpha 1 antitrypsin
  • Alphafetoprotein
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27
Q

Corresponding proteins: alpha 2 globulin

A
  • ceuloplasmin
  • haptoglobin
  • alpha 2 macroglobulin
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28
Q

Corresponding proteins: beta globulin

A
  • hemopoir
  • transterin
  • fibrinogen
  • lipoprotein
  • protein compliment system
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29
Q

Corresponding proteins: gamma region

A
  • antibodies/immunoglobulin
30
Q

Basic 4 chain polypeptide

A

2 large: heavy or H chain
2 small: light or L chain

31
Q

Chain held together by noncovalent forces

A

Disulfide linkage/bonds
Disulfide interchain bridge

32
Q

Structure of Immunoglobulins was first describe by two scientist.

A

Gerald Edelman and Rodney Porter

33
Q

Edelman’s work centered on using the__________________ to separate
out immunoglobulins on the basis of molecular weight.

A

analytical ultracentrifuge

34
Q

Immunoglobulin IgG product

A

Sedimentation coefficient rate

35
Q

IgG has

A

7s (svedberg unit)

36
Q

What use to unfold IgG

A

7 molar of urea

37
Q

Used reducing reagent of edelman

A

2-mercapthoethanol/ mercapthoethanol

38
Q

2 separate fractions in immunoglobulin IgG

A

3.5s = 50,000 dalton (heavy chain)
2.2s = 22,000 dalton (light chain)

39
Q

Year the won noble prize of edelman and porter

A

1972

40
Q

FAB mean

A

Fragment of antigen binding

41
Q

FC mean

A

Fragment crystallizable

42
Q

scientist discover papain digestion

A

Rodney porter

43
Q

Papain digestion has ______fragment

A

3 fragment

44
Q

Cleave of 3 fragment in papain digestion

A

2 fab (1 light chain; half heavy chain)
1 fc ( 2 half heavy chain)

45
Q

Where can you find na fab

A

Always in Y

46
Q

Where can you see Fc

A

Always in the body

47
Q

Scientist discover pepsin digestion

A

Alfred nisonoff

48
Q

Pepsin digestion has ______ fragment

A

2 fragment

49
Q

Cleave of 2 fragment in pepsin digestion

A

1 fab (2 light chain; 2 half heavy chain)
1 fc ( 2 half heavy chain; disintegrated inter small pieces)

50
Q

Structure of immunoglobulin

A

Variable region
Constant

51
Q

Variable region
Under:
Located:

A

Under: Fab
Located: amino terminal end

52
Q

Constant
Under:
Located:

A

Under: FC
Located: carbonyl terminal

53
Q

Domains involved by group

A

IgG, IgA, and IgD = GAD
IgM and IgE = ME

54
Q

Domains of IgG, IgA and IgD

A

Light chain: 2 domains
Heavy chain: 4 domains

55
Q

Domains of IgM and IgE

A

Light chain: 2 domain
Heavy chain: 5 domain

56
Q

Light chain discovered in abnormal protein to patient with

A

Multiple myeloma

57
Q

Kappa
Chromosome:
Amino acid:

A

Chromosome: 2
Amino acid: 200

58
Q

Lambda
Chromosome:
Amino acid:

A

Chromosome: 22
Amino acid: 220

59
Q

Heavy chain has amino acid

A

110 amino acid

60
Q

Immunoglobulin classes
IgG:
IgA:
IgM:
IgE:
IgD:

A

IgG: gamma chain
IgA: alpha chain
IgM: Mu chain
IgE: epsilon chain
IgD: delta chain

61
Q

Antibody variation

A

Isotype
Allotype
Idiotype

62
Q

Isotype is under

A

Heavy chain/ common immunoglobulin

63
Q

Allotype is under

A

Constant region, immunoglobulin subclasses and kappa

64
Q

Idiotype

A

Variable region

65
Q

Kappa allotype

A

IgG = 4 subclasses
IgA = 2 subclasses

66
Q

Hinge region composed of

A

Proline

67
Q

Make flexible of Ig and antigen binding works independently

A

Proline

68
Q

Basic immunoglobulin structure

A

Monomer
Dimer
Polymer

69
Q

Basic immunoglobulin structure and antigen binding site involved

A

Monomer: 2 antigen binding site
Dimer: 4 antigen binding site
Polymer: more than 4 antigen binding site

70
Q

Basic immunoglobulin structure according monomer

A

IgG, IgA (serum IgA/IgA 1), IgM (only found in area of b cell), IgE, IgD

71
Q

Basic immunoglobulin structure according dimer

A

IgA (secretory IgA/ IgA 2)

72
Q

Basic immunoglobulin structure according polymer/pentameric

A

IgM (largest)

Cchm Lec (5 decks)

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