Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Infectious Disease AB > Antifungals AB > Flashcards

Antifungals AB Flashcards

1
Q

Azole - mechanism?

A

Inhibit CYP450 needed for cell membrane ergosterol synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Azole - activity?

A

Flucon: C albicans
Vori: all candida, many aspergillus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Azole - toxicity?

A

Hepatic

Visual disturbance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Amphotericin B - mechanism?

A

Insertion into fungal cytoplasmic membrane with increased membrane permeability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Amphotericin B - activity?

A

Aspergillus
Cryptococcus
Mucormycosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Amphotericin B - mechanism of nephrotoxicity?

A

Vasoconstriction of afferent arterioles

K/Mg/HCO3 wasting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Echinocandins - mechanism?

A

Inhibit glucan synthase, required for fungal cell wall

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Echinocandins - activity?

A 
All candida (except parapsilosis) 
Aspergillus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Flucytosine - mechanism?

A

Fluorine analogue of cytoside

Deaminated to 5-FU - inhibits DNA synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Flucytosine - activity?

A

Cryptococcus in combination therapy

Candida

How well did you know this?
1
Not at all
2
3
4
5
Perfectly

Infectious Disease AB (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions