Antifungals AB Flashcards

1
Q

Azole - mechanism?

A

Inhibit CYP450 needed for cell membrane ergosterol synthesis

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2
Q

Azole - activity?

A

Flucon: C albicans
Vori: all candida, many aspergillus

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3
Q

Azole - toxicity?

A

Hepatic

Visual disturbance

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4
Q

Amphotericin B - mechanism?

A

Insertion into fungal cytoplasmic membrane with increased membrane permeability

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5
Q

Amphotericin B - activity?

A

Aspergillus
Cryptococcus
Mucormycosis

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6
Q

Amphotericin B - mechanism of nephrotoxicity?

A

Vasoconstriction of afferent arterioles

K/Mg/HCO3 wasting

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7
Q

Echinocandins - mechanism?

A

Inhibit glucan synthase, required for fungal cell wall

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8
Q

Echinocandins - activity?

A
All candida (except parapsilosis) 
Aspergillus
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9
Q

Flucytosine - mechanism?

A

Fluorine analogue of cytoside

Deaminated to 5-FU - inhibits DNA synthesis

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10
Q

Flucytosine - activity?

A

Cryptococcus in combination therapy

Candida

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