Antifungals AB Flashcards
Azole - mechanism?
Inhibit CYP450 needed for cell membrane ergosterol synthesis
Azole - activity?
Flucon: C albicans
Vori: all candida, many aspergillus
Azole - toxicity?
Hepatic
Visual disturbance
Amphotericin B - mechanism?
Insertion into fungal cytoplasmic membrane with increased membrane permeability
Amphotericin B - activity?
Aspergillus
Cryptococcus
Mucormycosis
Amphotericin B - mechanism of nephrotoxicity?
Vasoconstriction of afferent arterioles
K/Mg/HCO3 wasting
Echinocandins - mechanism?
Inhibit glucan synthase, required for fungal cell wall
Echinocandins - activity?
All candida (except parapsilosis) Aspergillus
Flucytosine - mechanism?
Fluorine analogue of cytoside
Deaminated to 5-FU - inhibits DNA synthesis
Flucytosine - activity?
Cryptococcus in combination therapy
Candida