Antifungal Drugs

Question 1

Describe/Name Topical Antifungals

Answer 1

Mico, Clotri and KENT are Topical friends
1. Miconazole
2. Clotrimazole
3. Ketoconazole
4. Econazole
5. Nystatin
6. Terbinafin

Question 2

describe/name the systemic antifungals

Answer 2

Systems AT AGE
1. Azoles
2. Terbinafine
3. Amphotericin B
4. Griseofulvin
5. Echinocandins

Question 3

Describe MOA, Route of admission, A/E, Indications and D/I of Amphotericin B

Answer 3

MOA-Binds to Ergosterol and forms pores
Route=IV only
Indications=Candida, Aspergillus, cryptococcus etc.
A/E= Nephrotoxicity, Hypokalaemia and Hypomagnesaemia
D/I= Aminoglycosides, Digoxin, Diuretics.

Question 4

Describe the indications, route and side effects of nystatin.

Answer 4

indications= Superficial Oral and vaginal candidiasis
route= cream
Side Effects= Unpleasant taste.

it is safe to use in infants.

Question 5

Describe the MOA, Indications, route and Side effects of Caspofungi

Answer 5

Moa= Inhibits fungal cell wall synthesis
Indications= Systemic candiadiasis and aspergillus
Route of Administration= IV only
Side Effects= Minor GIT effects but well tolerated.

Question 6

Describe the Mech. of action of Azoles

Answer 6

Inhibits fungal p450 enzymes
Inhibits ergosterol synthesis by inhibiting 14-demethylase

Question 7

Describe the Indication, Admin. route, A/e, D/I for Fluconazole

Answer 7

Indications= Candidiasis(systemic, oral, vaginal), Cryptococal Meningitis.
A/E= Rash
D/I= Inhibits cytP450 enzymes

long plasma half life.

IV and Oral

Question 8

Describe the indications, Admin route and side effects of Itraconazole.

Answer 8

Indication= Candidiasis, Dermatophytes, Dimorphic fungal infections
Admin=Oral
A/E= Hepatotoxic

Question 9

Describe the INdications, Route of Admin, A/e amd DI of Voriconazole

Answer 9

Indications= Candidiasis and Aspergillosis

Given Orally

A/E
1. Visual disturbance.
2. Hepatotoxicity.
3. PS dermatitis.

D/I= Inhibits cytp450 enzymes

Question 10

Describe the Indications, Route of Admin. for Ketoconazole

Answer 10

Indication
1.Dermatophytes
2.Seborrheic Dermatitis
3.Pityriasis Versicolor.

Admin= Topically

Question 11

Describe the Indications and Route of admin for Clotrimazole

Answer 11

Indications
1. Oral Candidiasis
2. Vaginal Candidiasis
3. Dermatophytes

**given topically

Question 12

Describe the Noa, indications, pk and AEs of Griseofulvin

Answer 12

Inhibits fungal mitosis

Oral admin. Indicated in systemic Rx of dermatophytosis

AEs include, Headaches, Skin rash, altered taste, Xerostomia