Antifungal And Antiviral Agents

Question 1

What is the mechanism of action for amphotericin B

Answer 1

Binds with ergosterol and disrupt fungal cell membrane and alter permeability of the cell, which causes leakage of intracellular ions and enzymes leading to cell death

Question 2

Mechanism of resistance to amphotericin B

Answer 2

Ergosterol binding is decreased by membrane concentration of ergosterol