Antifungal - Amphotericin B

Question 1

Classification

Answer 1

1. Antibiotics: a. Amphotericin b
Micafungin, griseofulvin
2. Anti metabolites : Flucytosine
3. Azoles: Imidazoles
    Topical- clotrimazole
     Systemic - keto comas ole
     Triazoles- fluconazoles
4. Terbinafine

Question 2

MOA

Answer 2

Bonds tightly to ergosterol in fungal cell membrane and form pores and channels that leaks out intracellular contents.

Question 3

Kinetics

Answer 3

No Gut absorption
Highly bound to plasma proteins
Doesn’t cross BBB
Metabolized in liver
Excreted in urine and bile

Question 4

Adverse effects

Answer 4

Most toxic of all antifungals
Fever chills headache dyspnoea GI disturbances
Anaemia
Nephrotoxicity

Question 5

Uses

Answer 5

Drug of choice for mucormycosis
Aspergillosis cryptococcosis histoplasmosis blastomycosis
In leishmaniasis