Antifungal Agents

Question 1

What is Amphtotericin B and what’s it indicated for. State MOA

Answer 1

Broad Spectrum Antifungal. It exhibits selective toxicity Binding to the ergosterol in fungal cell wall membranes, not cholesterol in human cell walls. It damages the fungal membrane, causing pores. This compromises the membrane integrity, leading to leakage of fungal metabolites

Treatment of Serious systemic infections caused by Candida Albicans

Question 2

Fluconazole + Itraconazole MOA and Activity

Answer 2

Inhibits fungal enzyme used in sterol synthesis (lanosterol 14 alpha-demethylase)

• > this blocks ergosterol synthesis
• > inhibits fungal froth

Broad spectrum Fungistatic

Treatment of Candida

Question 3

Terbinafine MOA and Activity

Answer 3

Inhibits squalene monooxygenase

> blocks ergosterol synthesis

Broad spectrum Fungicidial

Hydrophobic + Accumulates in human keratin protein over time.

Treatment of Fungal nail infections