antifungal

Question 1

skin fungal infections called

Answer 1

dermatomycosis

Question 2

what can cause dermatomycosis

Answer 2

immune deficiencies, transplant, large does antibacterials

Question 3

targets of anti fungal agents

Answer 3

microtubules
cell wall
cell membrane
nucleus

Question 4

what does fungal cell walls contain

Answer 4

ergosterol

Question 5

dermatomycoses

Answer 5

sacrophites

Question 6

skin fungal use what as energy source

Answer 6

keratin

Question 7

ringworm is….

Answer 7

fungal infection of the skin, raised mark in a circle on skin

Question 8

fungal infection of mucus membrane called what

Answer 8

candidiosis

Question 9

agents that are used topically to treat skin infections

Answer 9

polyene antibiotics
for ringworm
for candida and ringworm

Question 10

polyene antibiotics

Answer 10

nystatin
amphotericin B
natamycin

Question 11

for ringworm

Answer 11

tolnaftate
ciclopirox
terbinafine

Question 12

for candida and ringworm

Answer 12

miconazole and other “conazole” s

Question 13

nystatin and other polyene MOA

Answer 13

bind to ergosterol in fungal cell membranes and will form pores, causing membrane leakage

Question 14

what ways can you give nystatin?

Answer 14

orally if its an infection of the gut
mainly topical
too toxic for parental use

Question 15

can you give nystatin perentally?

Answer 15

NO

Question 16

what is aphotericin B used for

Answer 16

systemically

Question 17

what is natamycin used for?

Answer 17

antifungal used for the eye

Question 18

what way are terbinafine, miconazole used?

Answer 18

systemically (why they are in the topically section i have no fucking clue)

Question 19

agents that are given systemically to treat fungal infections of the skin

Answer 19

griseofluvin

terbinafine

Question 20

how is amphotericin B used

Answer 20

systemically for systemic fungal infections

Question 21

griseofluvin used for treatment of what

Answer 21

toe/finger nail fungal infections, dont want to take nail off or drill hole in nail so you use medicine systemically

Question 22

griseofluvin MOA

Answer 22

binds to fungal microtubules and inhibits fungal mitosis

Question 23

T/F griseofluvin is absorbed well and not excreated

Answer 23

FALSE, not absorbed well and most excreated unchanged.

Question 24

griseofluvin is taken up by what?

Answer 24

growing human skin cells and concentrated in keratin

Question 25

S.E. of griseofluvin

Answer 25

headache induce P450 derived from penicillin mold, allergic rxn

Question 26

terbinafine is a ____

Answer 26

enzyme inhibitor

Question 27

terbinafine MOA

Answer 27

inhibits enzyme squaline expoidase, inhibits ergosterol synthesis

Question 28

S.E. of terbinafine

Answer 28

inhibits P450

Question 29

T/F squaline is toxic

Answer 29

true

Question 30

some systemic mycoses

Answer 30

histoplasmosis candida aspergillas mycomycosis

Question 31

what is the DOC for systemic fungal infections

Answer 31

amphotericin B

Question 32

how do you give amphotericin B

Answer 32

2-4 month slow IV or interthecal, not absorbed orally.

Question 33

amphotericin B is an fungalcidal T/F

Answer 33

true

Question 34

S.E. of amphotericin B

Answer 34

"amphoteribble"- impaired renal function- can kill kidney if you use this drug with other nephrotoxic drugs fever, chills, headache, vomiting anemia

Question 35

azoles

Answer 35

derivatives the conazoles

Question 36

two groups of azoles

Answer 36

imidazoles | triazoles

Question 37

imidazoles

Answer 37

ketoconazole

Question 38

triazoles

Answer 38

``` fluconazole itraconazole posaconazole voriconazole flucytosine ```

Question 39

ketoconazole is a _____

Answer 39

enzyme inhibitior

Question 40

ketoconazole MOA

Answer 40

inhibits lanosterol 14- alpha dexmethlane synthase, inhibits ergosterol synthase

Question 41

S.E. of ketoconazole

Answer 41

``` Gi upset- nausea inhibits P450 hepatotoxicity decreases cortisol and testosterone- used to treat cushing and prostatic cancer (GIH) ```

Question 42

what drug is used to treat prostatic cancer and cushing disease?

Answer 42

ketoconazole

Question 43

triazoles have ____ effect on P450 than imidazoles

Answer 43

less

Question 44

triazoles are _____

Answer 44

fungistatic

Question 45

fluconazole

Answer 45

least to lowest effect on human P450

Question 46

S.E. of fluconazole

Answer 46

tetrogenic hallucinations liver damage

Question 47

itraconazole

Answer 47

strongest effect on human P450

Question 48

S.E. of itraconazole

Answer 48

heart | worsens CHF or arrythmias

Question 49

S.E. of voriconazole

Answer 49

cause visual disturbances.

Question 50

flucytosine is a

Answer 50

pyrimidine analog, prodrug

Question 51

flucytosine MOA

Answer 51

inhibits thymidine synthesis in fungi. converted to 5-flurouracil in fungus- inhibits enzyme thymidilate synthase

Question 52

flucytosine is used with what

Answer 52

amphoteracin B

Question 53

T/F terbinafine is a what

Answer 53

allylamine

Question 54

echinocandins

Answer 54

caspofungin micafungin anidulafungin

Question 55

anidulafungin MOA

Answer 55

inhibits enzyme. inhibits synthesis of fungal cell wall components

Question 56

how is anidulafungin given

Answer 56

slow IV- 91 hours

Question 57

S.E. of anidulafungin

Answer 57

rash fever fetal damage