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Zak, Neuro 2 > Antiepileptic Medications > Flashcards

Antiepileptic Medications Flashcards

1
Q

Which drug(s) enhance the fast-activation Na channel gate?

A

Carbamazepine, Oxcarbazepine, Eslicarbazepine, Lacosamide, Lanotrigine, Phenytoin, Valproic acid, Zonisamide, Topiramate, Rufinamide

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2
Q

Which drug(s) enhance the slow-activation Na channel gate?

A

Lacosamide

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3
Q

Which drug(s) enhance GABA via GAT-1 inhibition?

A

Tiagabine

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4
Q

Which drug(s) enhance GABA via GABA-T inhibition?

A

Vigabatrine, Valproic acid

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5
Q

Which drug(s) are GABAa agonists?

A

Penobarbitol, Primidone, Clonazepam, Clorazepate, Lorazepam, Diazepam, Topiramate

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6
Q

Which drug(s) inhibit T-type Ca channels?

A

Ethosoximide, Valproic acid, Zonisamide

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7
Q

Which drug(s) act as antagonists on AMPA receptors?

A

Topiramate, Perampanol

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8
Q

Which drug(s) act as antagonists on NMDA receptors?

A

Felbamate

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9
Q

Which drug(s) inhibit Protein-2A?

A

Levetiracetam, Brivaracetam

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10
Q

Which drug(s) inhibit a2d-Ca channels?

A

Gabapentin, Pregabaliin

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11
Q

Which drug are the barbiturates?

A

Phenobarbitol, Primidone

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12
Q

Which drugs are the Benzodiazepines?

A

Clonazepam, Clorazepate, Lorazepam, Diazepam

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13
Q

What are all the MOA’s that Valproic acid can be used for?

A

Enhance fast-activation gate of Na channel, Inhibit GABA-T, Inhibit T-type Ca channels

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14
Q

What are all the MOA’s that Lacosamide can be used for?

A

Enhance fast and slow-activation gates of Na channels

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15
Q

What are all the MOA’s that Zonisamide can be used for?

A

Enhance fast-activation gate of Na channels, Inhibit T-type Ca channel

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16
Q

What are all the MOA’s that Topiramate can be used for?

A

Enhance fast-activation gate of Na channels, GABAaR agonist, AMPA antagonist

17
Q

Which drug(s) inhibit conjugation with UGT?

A

Valproic acid, Lamotrigine

18
Q

Which drug(s) induce conjugation with UGT?

A

Phenytoin, Phenobarbital, Carbamazepine

19
Q

Which drug requries a CBC when administered?

A

Carbamazepine

20
Q

Which drug requires regular eye exams/vision tests when administered?

A

Vigabatrin

21
Q

Which drug undergoes auto-induction?

A

Carbamzepine

22
Q

Which drug is zero-order?

A

Phenytoin

23
Q

What are the 3 major drug-drug interactions of all AED’s?

A

Increase BC clearance, Warfarin clearance, HIV medication clearance

24
Q

What are the 1st choice drugs for Status Epilepticus?

A

Lorazepam, Diazepam

25
Q

What are the 2nd choice drugs for Status Epilepticus?

A

Phenytoin, Phenobarbital, Valproic acid, Levetiracetam

26
Q

Which drugs exhibit good broad spectrum use?

A

Carbamazepine, Phenobarbital, Phenytoin, Topiramate, Valproic acid

27
Q

Which drugs are best for Absence seizures?

A

Valproic acid, Ethasuximide, Clonazepam

28
Q

Which drug is best for Myoclonic seizures?

A

Clonazepam

29
Q

Which drug is best for Tonic/Clonic seizures?

A

Primidone

30
Q

Which drugs are best for Partial seizures?

A

Primidone, Clorazepate, Eslicarbazepine, Oxcarbazepine, Felbamate, Lamotrigine, Lacosamide, Zonisamide

Zak, Neuro 2 (7 decks)

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