Antiepileptic Medications

Question 1

Which drug(s) enhance the fast-activation Na channel gate?

Answer 1

Carbamazepine, Oxcarbazepine, Eslicarbazepine, Lacosamide, Lanotrigine, Phenytoin, Valproic acid, Zonisamide, Topiramate, Rufinamide

Question 2

Which drug(s) enhance the slow-activation Na channel gate?

Answer 2

Lacosamide

Question 3

Which drug(s) enhance GABA via GAT-1 inhibition?

Answer 3

Tiagabine

Question 4

Which drug(s) enhance GABA via GABA-T inhibition?

Answer 4

Vigabatrine, Valproic acid

Question 5

Which drug(s) are GABAa agonists?

Answer 5

Penobarbitol, Primidone, Clonazepam, Clorazepate, Lorazepam, Diazepam, Topiramate

Question 6

Which drug(s) inhibit T-type Ca channels?

Answer 6

Ethosoximide, Valproic acid, Zonisamide

Question 7

Which drug(s) act as antagonists on AMPA receptors?

Answer 7

Topiramate, Perampanol

Question 8

Which drug(s) act as antagonists on NMDA receptors?

Answer 8

Felbamate

Question 9

Which drug(s) inhibit Protein-2A?

Answer 9

Levetiracetam, Brivaracetam

Question 10

Which drug(s) inhibit a2d-Ca channels?

Answer 10

Gabapentin, Pregabaliin

Question 11

Which drug are the barbiturates?

Answer 11

Phenobarbitol, Primidone

Question 12

Which drugs are the Benzodiazepines?

Answer 12

Clonazepam, Clorazepate, Lorazepam, Diazepam

Question 13

What are all the MOA’s that Valproic acid can be used for?

Answer 13

Enhance fast-activation gate of Na channel, Inhibit GABA-T, Inhibit T-type Ca channels

Question 14

What are all the MOA’s that Lacosamide can be used for?

Answer 14

Enhance fast and slow-activation gates of Na channels

Question 15

What are all the MOA’s that Zonisamide can be used for?

Answer 15

Enhance fast-activation gate of Na channels, Inhibit T-type Ca channel

Question 16

What are all the MOA’s that Topiramate can be used for?

Answer 16

Enhance fast-activation gate of Na channels, GABAaR agonist, AMPA antagonist

Question 17

Which drug(s) inhibit conjugation with UGT?

Answer 17

Valproic acid, Lamotrigine

Question 18

Which drug(s) induce conjugation with UGT?

Answer 18

Phenytoin, Phenobarbital, Carbamazepine

Question 19

Which drug requries a CBC when administered?

Answer 19

Carbamazepine

Question 20

Which drug requires regular eye exams/vision tests when administered?

Answer 20

Vigabatrin

Question 21

Which drug undergoes auto-induction?

Answer 21

Carbamzepine

Question 22

Which drug is zero-order?

Answer 22

Phenytoin

Question 23

What are the 3 major drug-drug interactions of all AED’s?

Answer 23

Increase BC clearance, Warfarin clearance, HIV medication clearance

Question 24

What are the 1st choice drugs for Status Epilepticus?

Answer 24

Lorazepam, Diazepam

Question 25

What are the 2nd choice drugs for Status Epilepticus?

Answer 25

Phenytoin, Phenobarbital, Valproic acid, Levetiracetam

Question 26

Which drugs exhibit good broad spectrum use?

Answer 26

Carbamazepine, Phenobarbital, Phenytoin, Topiramate, Valproic acid

Question 27

Which drugs are best for Absence seizures?

Answer 27

Valproic acid, Ethasuximide, Clonazepam

Question 28

Which drug is best for Myoclonic seizures?

Answer 28

Clonazepam

Question 29

Which drug is best for Tonic/Clonic seizures?

Answer 29

Primidone

Question 30

Which drugs are best for Partial seizures?

Answer 30

Primidone, Clorazepate, Eslicarbazepine, Oxcarbazepine, Felbamate, Lamotrigine, Lacosamide, Zonisamide