Antiemetics / emetics pharm

Question 1

Drug classes for antiemetics

Answer 1

5-HT3 antagonists;
DA antagonists;
Cannabinoids

Question 2

What are the agents from 5-HT3 antagonists? where do they act?

Answer 2

Ondansetron; Granisetron; dolasetron

chemoreceptor trigger zone; peripheral sites

Question 3

What are agents of DA antagonists? action?

Answer 3

phenothiazine; metoclopramide

block D2 receptors in chemoreceptor trigger zone

Question 4

What are agents of cannbinoids? important fact

Answer 4

Dronabinol

active ingredient in marijuana

Question 5

What are the 2 emetic drugs?

Answer 5

ipecac;

apomorphine

Question 6

How does ipecac work? what happens if it does not?

Answer 6

locally irritates GI tract and stimulates chemoreceptor trigger zone => if emesis does not occur in 20min then must be removed

Question 7

how does apomorphine work? how fast?

Answer 7

dopamine receptor agonist that stimulates chemoreceptor trigger zone => works w/in 5 min