Antiemetics and Antitussives

Question 1

Prochlorperazine (Compazine)

Answer 1

Dopamine D2 antagonist

Primary action on the CRTZ

Question 2

Metoclopramide (Reglan)

Answer 2

D2 dopamine antagonist

Primary target is CRTZ, but also acts on enteric nerves to increase GI tone and motility

Question 3

Ondansetron (Zofran)

Answer 3

5-HT3 Antagonists (serotonin)

Anti N/V in cancer chemotherapy

Question 4

Granisetron (Kytrill)

Answer 4

5-HT3 Antagonists (serotonin)

Anti N/V in cancer chemotherapy

Question 5

Dronabinol (Marinol)

Answer 5

THC

N/V control during chemotherapy

Question 6

Aprepitant (Emend)

Answer 6

NK1 (neurokinin) antagonist

N/V control during chemotherapy

Question 7

Pyridoxine (vitamin B6)

Answer 7

N/V control during pregnancy

Question 8

Codeine, hydrocodone

Answer 8

Opioids

Most effective antitussives

Question 9

Dexteomethorphan

Answer 9

Non-opioid antitussive
Available OTC (Benylin DM, Pertussin, Vicks formula 44)

Question 10

Benzonatate (Tessalon)

Answer 10

Desensitize airway receptors

Antitussive

Question 11

Guaifenesin

Answer 11

Expectorant

Activates mucus production reflex

Question 12

Acetylcysteine (Mucomyst)

Answer 12

Mucolytic agent