Antiemetics

Question 1

Serotonin receptor blockers (5HT blockers)

Answer 1

Ondansetron (Zofran)
Dolasetron (Anzemet)

Indications: chemo / radiation
SE: HA, dizziness, hypotension

Question 2

Dopamine receptro antagonists (DA2 receptor blockers)

Answer 2

prochlorperazine (Compazine)
promethazine (Phenergan)
droperidol (Inapsine)
haloperidol (Haldol)
Metoclopramide (Reglan)

Indications: chemo/radiation / drug induces emesis
SE: extrapyramidal effects (EPS)

Question 3

Glucocorticoids

Answer 3

methylprednisone (Solumedrol)
dexamethasone (Decadron)

MOA: unclear
SE: over/long term use = Cushing’s symptoms (moon face, buffalo hump

Question 4

Cannabinoid

Answer 4

dronabinol (Marinol)

Indications: CINV; approved for appetite stimulant (AIDS, elderly pts)
SE: tachycardia; potential for abuse

Question 5

Prokinetic agents (promotility)

Answer 5

metoclopramide (Reglan)

↓ NV associated w/chemo
⇡GI motility