ANTIDOTES Flashcards
Benzodiazepine Toxicity
Flumanezil
Heparin Toxicity
Protamine Sulfate
Warfarin Toxicity
Vitamin K, Fresh Frozen Plasma
Warfarin’s mechanism of action
decreased blood clotting by blocking enzyme called Vitamin K epoxide reductase that reactivates Vitamin K
Warfarin affects ___________ pathway.
extrinsic pathway
Clotting factors affected by warfarin?
Clotting Factors 1972 (10, 9, 7, 2)
Alteplase, Streptokinase Toxicity
Aminocaproic Acid / Tranexamic Acid
What does Tranexamic Acid inhibit?
Activation of Plasminogen
reduces amount of plasmin that can be produced, thereby slowing the amount of clot degradation
Opioid Toxicity
Naloxone
Cyanide (CN-) Toxicity
Sodium Thiosulfate
Amyl Nitrite pearls / 3 1/2 Sodium Nitrite
Digitalis Toxicity
Anti dig Fab Fragments (Digi Bind)
Lead (Pb) Toxicity
Edetate Calcium Disodium (EDTA)
Mercury, Arsenic, Cadmium Toxicity
British antilewisite (BAL) a.k.a Dimercaprol
Copper Toxicity
Penicillamine
Iron Toxicity
Deferroxamine