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Pharmacology > Antidiabetics MOA > Flashcards

Antidiabetics MOA Flashcards

1
Q

Insulin (MOA)

A

Activate insulin receptors

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2
Q

Sulfonylureas (MOA)

A

Insulin secretagogues: close k channels in b cells
increase insulin release

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3
Q

Glitinides (MOA)

A

Insulin secretagogues: similar to sulfonylureas with some overlap in binding sites

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4
Q

Biguanides (MOA)

A

Obscure: reduced hepatic and renal gluconeogenesis

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5
Q

Alpha-Glucosidase Inhibtors (MOA)

A

Inhibit intestinal a-glucosidase

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6
Q

Thiazolidinediones (Pioglitazone) (MOA)

A

Regulates gene expression by binding to PPAR-y and PPAR-a

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7
Q

Thiazolidinediones (Rosiglitazone) (MOA)

A

Regulates gene expression by binding to PPAR-y

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8
Q

Glucagon-like Polypeptide-1 receptor agonists (MOA)

A

Analog of GLP-1: Binds to GLP-1 Receptors

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9
Q

Dipeptidyl Peptidase-4 inhibitors (MOA)

A

DPP-4 inhibitor: Block degradation of GLP-1
Raises circulating GLP-1 levels

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10
Q

Amylin Analog (MOA)

A

Analog of amylin: binds to amylin receptors

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11
Q

Bile acid sequestrant (MOA)

A

Bile acid binder

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12
Q

SGLT2 Inhibitors (MOA)

A

Inhibit renal glucose absorption via SGLT2

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13
Q

Activate insulin receptors

A

Insulin

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14
Q

Insulin secretagogues: close k channels in b cells
increase insulin release

A

Sulfonylureas

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15
Q

Insulin secretagogues: similar to sulfonylureas with some overlap in binding sites

A

Glitinides

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16
Q

Obscure: reduced hepatic and renal gluconeogenesis

A

Biguanides

17
Q

Inhibit intestinal a-glucosidase

A

Alpha-Glucosidase inhibitors

18
Q

Regulates gene expression by binding to PPAR-y and PPAR-a

A

Thiazolidinediones (Pioglitazone)

19
Q

Regulates gene expression by binding to PPAR-y

A

Thiazolidinediones (Rosiglitazone)

20
Q

Analog of GLP-1: Binds to GLP-1 Receptors

A

Glucagon-like Polypeptide-1 receptor agonists

21
Q

DPP-4 inhibitor: Block degradation of GLP-1
Raises circulating GLP-1 levels

A

Dipeptidyl Peptidase-4 inhibitors

22
Q

Analog of amylin: binds to amylin receptors

A

Amylin Analog

23
Q

Bile acid binder

A

Bile acid sequestrant

24
Q

Inhibit renal glucose absorption via SGLT2

A

SGLT2 inhibitors

Pharmacology (4 decks)

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