Antidepressants and Mood Stabilizers Flashcards
SSRI with longest half life, is the most stimulating, and is associated with the least amount of weight gain
fluoxetine (Prozac)
Which SSRI has the highest risk for serotonin syndrome due to it’s long half life?
fluoxetine (Prozac)
Which two SSRIs are associated with the least amount of sexual adverse effects?
Citalopram (Celexa) and Escitalopram (Lexapro)
Which SSRI has the highest risk of GI problems?
sertraline (Zoloft)
Which SSRI has the shortest half life, is the most sedating, causes the most weight gain, has greatest sexual adverse effects, and greatest anticholinergic activity?
paroxetine (Paxil)
Symptoms include: shivering, hyperreflexia, myoclonus, ataxia, n/v/d
serotonin syndrome
Which SNRI is sedating and causes HTN?
venlafaxine (Effexor)
Which SNRI has less adverse effects and works well for fibromyalgia, sleep and pain?
duloxetine (Cymbalta)
Which category of antidepressants may be more effective in the setting of diabetic neuropathy, fibromyalgia, mask pain, stress incontinence, sedation, fatigue, and comorbid anxiety?
SNRIs
Name the atypical antidepressant that may increase sexual fxn and is good for comorbid ADHD
Buproprion (Wellbutrin)
What mental health disorders contraindicate the use of Buproprion (wellbutrin) as antidepressant med?
anxiety (adverse effect) or eating disorder (weight loss is adverse effect)
Name the atypical antidepressant that is the most sedating of ALL antidepressants, but its overdose is generally safe
mirtazapine (Remeron)
What adverse effect is associated with trazodone (oleptro)?
priapism
What is the MOA of TCAs?
inhibits the reuptake of both serotonin and norepi
Name the TCA that is good for sleep, pain, and depression
amitripyline (Elavil)
Name the TCA that is the least sedating
desipramine (norpramin)
What is the main adverse effect of all TCAs?
anticholinergic
What is the brand name for generic TCA agent clomipramine?
anafranil
What is the brand name for the generic TCA agent doxepin?
silenor
What is the brand name for the generic TCA agent imipramine?
tofranil
What is the brand name for the generic TCA agent nortriptyline?
pamelor
What is the MOA of MAOIs?
block destruction of monoamines centrally and peripherally
What type of diet is necessary for patients receiving MAOIs?
tyramine free (no wine, beer, cheese, aged food, or smoked meats)
How long must you wait before intiating therapy with a MAOI if the patient was previously on other antidepressants?
2 weeks in order to prevent serotonin syndrome
Name the MAOI that is reversible and administered transdermally
selegiline (Emsam)
Name the two MAOIs that are irreversible
phenelzine (Nardil) and tranylcypromine (Parnate)
Mood stabilizer that is an antiepileptic and works by inhibiting voltage-gated Na+ channels
Carbamazepine (Tegretol)
What meds does carbazepine (Tegretol) decrease the effectiveness of?
OCPs and warfarin
What condition is contraindicated with the use of carbazepine (Tegretol)?
bone marrow depression
What pregnancy category is carbazepine (Tegretol), valproate (Depakote), and lithium (Eskalith)?
D
What needs to be monitored with carbazepine (Tegretol) use?
CBC, LFTs, mental status, bone density, levels
Mood stabilizer that is antiepileptic and increases GABA
Valproate (depakote)
What needs to be monitored with valproate (depakote) use?
CBC, LFTs, levels
What condition is contraindicated with use of valproate (depakote)?
liver disease
Mood stabilizer that blocks voltage-gated Na+ channels and inhibits glutamate release
lamotrigine (Lamictal)
What pregnancy category is laotrigine (Lamictal)?
C
What mood stabilizer interacts with lamotrigine (Lamictal)?
valproate (Depakote)
Mood stabilizer that inhibits adenylate cyclase
lithium (Eskalith, Lithobid)
What two medical conditions that can be caused by lithium therapy?
diabetes insipidus and hypothyroidism
How often should a BMP and TSH be done for a pt receiving lithium therapy?
every 6-12 months
Mood stabilizer with adverse effects that include: somnolence, dizziness, ataxia, leukopenia, weight gain, and SJS
gabapentin (Neurontin)
