Antidepressants Flashcards
1
Q
Give the 7 examples of SSRIs.
A
Fluoxetine Citalopram Sertraline Paroxetine Fluvoxamine Vortioxetine
2
Q
Give the 7 examples of tricyclic antidepressants
A
Amitripityline Clomipramine Dosulpein Imipramine Lofepramine Nortiptyline Doxepin
3
Q
What are 2 examples of SNRIs?
A
Venlafaxine
Duloxetine
4
Q
What is agomelatine?
A
Its an agonist at melatonin receptor and antagonist at 5HT2c receptors
5
Q
What is mirtazepine?
A
It is an antagonist at central pre-synaptic alpha (2)-receptors. Increases both 5HT and NA
6
Q
What is Reboxetine?
A
Specific noradrenergic reuptake inhibitor
7
Q
What are the diagnostic features of depression?
A
- Persistent low mood
- Loss of interest in activities
- Altered sleep
- Fatigue
- Agitation, slow movements
- Poor concentration
- Suicidal thoughts
- Feelings of worthlessness
8
Q
What is the neurobiology of depression?
A
- Low monoamines (serotonin and noradrenaline)
- Hypothalamus pituitary adrenal (HPA) axes hyperactivity_ stress leads to increased cortisol levels and CRF leads to reduced niccocampus and neurogenesis
