Antidepressants Flashcards
What are anti-depressants?
Medications to treat depression.
Off label uses include anxiety, pain, and insomnia.
(non-FDA approved for ADHD in ADULTS)
What are the most common types used?
Most common drugs used are SSRIs, ex: Fluoxetine, Citalopram, Sertraline, Paroxetine, and Escitalopram.
SNRIs may be used (vanlafaxine and duloxetine), and Buproprion (a ketoamine/NDRI drug also used in smoking cessation and SADD).
Older and less used are the tri and tetracyclics, as well as MAOIs.
How do patients respond?
Some people respond to some and not others, the cause of which is unknown.
Must ensure use and dosage are done correctly for at least 4-6 weeks to see effectiveness.
Always make sure to taper off medication so the body can adjust. There is NO addictive quality to these drugs.
Side effects of antidepressants.
Nausea, vomiting, weight gain, diarrhea sleepiness, and sexual dysfunction.
Combining SSRI or SNRI with a triptan medication (used in migraines) can cause serotonin syndrome. Use of MAOIs can also cause serotonin syndrome.
Escitalopram
Cipralex, SSRI
Use in depression, anxiety, and OCD.
10-20mg dosing
Sertraline
Zoloft, SSRI
Use in depression, OCD, panic disorders, PTSD, premenstrual dysphoric disorder, and social phobia in ADULTS.
Use in CHILDREN with OCD ages >6.
25-200mg dosing.
Citalopram
Celexa, SSRI
Use in depression/MDD and OCD.
10-60mg dosing.
Fluoxetine
Prozac, SSRI
Use in depression, bulimia, MDD, OCD, panic disorder and premenstrual dysphoric disorder.
In CHILDREN: MDD in ages >8 and OCD >7.
10-60mg dosing.
Paroxetine
Paxil, SSRI
Use in depression/MDD, GAD OCD (primary indication), panic disorder, PTSD, premenstrual dysphoric disorder, and social phobia.
10-60mg dosing.
Fluvoxamine
Luvox, SSRI
Use is primarily OCD (in adults and children >8) and social phobia. But can also be used for depression, eating disorders, and chronic tension headaches.
50-300mg dosing.
Venlafaxine
Effexor, SNRI
Use in MDD, GAD, panic disorders, and social phobia. Sometimes used in OCD or fibromyalgia.
37.5-225mg dosing.
Desvenlafaxine Succinate
Pristiq, SNRI
Use in depression/MDD.
50-100mg dosing.
Duloxetine
Cymbalta, SNRI
Use in MDD, GAD, diabetic peripheral neuropathy, fibromyaldia, and chronic MSK pain.
60-120mg dosing.
Mirtazaepine
Remeron, NaSAA (tetracyclic antidepressant)
Use in MDD, anxiety, dysthymia, OCD and panic disorder. In low doses may be used for insomnia as an off label due to its hypnotic effects.
15-45mg PO HS dosing.
Buproprion
Wellbutrin, NDRI
Use in MDD, depression with seasonal changes, and smoking cessation. Can also be used for ADHD, bipolar disorders (depressive phase only), chronic fatigue syndrome, and lower back pain. Smoking cessation is also an indication.
150-300mg dosing.
