Antidepressants

Question 1

What are the SEs of SSRIs?

Answer 1

Anorexia
Wt loss
Sexual dysfunction 
Seizures 
Hypomania ! Can precipitate it in bipolar disorser

Question 2

What are SNRIs?

Answer 2

Serotoning -Norepinephrine reuptake inhibitors- potent inhibitors of sero and norepinephrine-
They are second generation agents- with SSRIs have replaced 1st generation like Tricyclics and MAOIs.

Venlafaxine (also used for generalised anxiety)
Milnacipran
Dullxethine

SE: apperite loss, wr loss, sleep loss.

Question 3

What is used for refractory and atypical depression?

Answer 3

Monoamine oxidase inhibitors- inhibit breakdown of serotonin by irriversibly inactivating enzymes- serotonin syndrome ( 2 drugs increase it- medical emergency- rarely used due to many SE

Phenelizine

Question 4

What are tricyclics?

Answer 4

Block the re-uptake of noradrenaline and serotonin at the pre-synaptic membrane.

They increase monoamines in the synaptic cleft.
Amitriptyline
Imipramine
Notriptyline

Question 5

What are common SE of TCAs?

Answer 5

Dry mouth
Blurred vision
Urinary retention

Question 6

What are SSRIs?

Answer 6

Selective serotoning reuptake ingibitors- from synaptic cleft
NICE
as a 1st line tx in Depresion.
Can take up to 2-6w.

Fluoxetine- only one that can be given to kids
Citalopram
Paroxetine
Sertaline