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5 - Pharmacology > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

Give the main classes of anti-depressants

A

SSRIsSNRIsTricyclic antidepressantsMonoamine oxidase inhibitors

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2
Q

Give some SSRIs

A

FluoxetineCitalopramParoxetine

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3
Q

Mechanism for SSRIs

A

Inhibit serotonin reuptake into nerve terminals in the synaptic cleft- very little effect on NA

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4
Q

Give some common ADRs for SSRIs

A

AnorexiaNauseaDiarrhoea These normally settle within a few weeks.

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5
Q

Give a drug-drug interaction of SSRIs

A

SSRI and MAOI- can cause serotonergic syndrome - autonomic disturbance, neuromuscular dysfunction and altered mental state.

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6
Q

Give some SNRIs

A

VenlafaxineDuloxetine

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7
Q

Mechanism for SNRIs

A

Inhibits re-uptake of both serotonin and noradrenaline- potentiates neurotransmitter activity- is dose dependentHigh dose = blocks NALow dose = blocks 5-HT

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8
Q

ADRs of SNRIs

A

Anorexia Nausea Diarrhoea- settles within 2-3 weeksDry mouthHypertensionHyponatremiaSleep disturbances

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9
Q

Drug-drug interactions for SNRIs?

A

MAOIs- serotonergic syndrome

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10
Q

What is the first line treatment for depression?

A

SSRIsFollowed by SNRIs

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11
Q

Give some tricyclic antidepressants

A

AmitryptylineImipramineClomipramineLofepramine

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12
Q

What are the indications for TCAs?

A

Depression Neurological pain - amitryptyline OCD - clomipramine

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13
Q

Mechanism for TCAs

A

BLock NA and 5HT reuptakeAlso binds to H1, muscarinic and alpha 1 and 2 receptors.

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14
Q

ADRs for TCAs

A

Arrhythmias (NA block in heart)Dry mouth and constipation (muscarinic effects)Postural hypotension (alpha one block)Sedation (H1 block)

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15
Q

Give some MAOIs

A

PhenelzineTranylcypromineIsocarboxazid

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16
Q

Mechanism for MAOIs

A

Block monoamine oxidase, which metabolises monoamines. Inhibition of monoamine a gives the best antidepressant efficacy

17
Q

ADRs for MAOIs

A

HypertensionCNS stimulation (excitement adn tremor)Dry mouthBlurred vision

18
Q

Drug-drug interactions for MAOIs

A

Reduce metabolism of - barbituates- opioids- alcohol

19
Q

Pharmacokinetics of SSRIS

A

Completely absorbed by the gutLiver metabolismLong elimination half life so only need a once daily dose

20
Q

Pharmacokinetics of TCAs

A

Lipid solubleAbsorbed from the gutLong half lifeMetabolised by the liver

5 - Pharmacology (17 decks)

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