Antidepressants

Question 1

Name 5 classes of antidepressants

Answer 1

MAOI
TCA
SSRI
NARI
SNRI

Question 2

Symptoms of depression

Answer 2

• Misery, apathy, and pessimism
• Low self-esteem
• Indecisiveness, loss of motivation
(anhedonia)

• Retardation of thought and action
• Loss of libido
• Sleep disturbance and loss of appetite

Question 3

What is monoamine theory?

Answer 3

Deficits in monoamine neurotransmitters (noradrenaline and 5-HT) cause depression.

Question 4

Name an MAOI

Answer 4

Phenelzine

Question 5

Adverse effects of MAOIs

Answer 5

Postural hypotension
Restlessness & insomnia

Question 6

TCA MOA?

Answer 6

Monoamine reuptake inhibitor

Question 7

Name a TCA

Answer 7

Amitriptyline
Imipramine
Nortriptyline

Question 8

TCA adverse effects

Answer 8

Anticholinergic
- Dry mouth, blurred vision, constipation
Antihistamine
- Sedation
Alpha-1 adrenergic blockade
- Postural hypotension

Question 9

Name 2 SSRIs

Answer 9

Fluoxetine
Citalopram

Question 10

Adverse effects of SSRIs

Answer 10

Nausea
Insomnia
Sexual dysfunction

(Citalopram has a bit of antihistamine action - sedation)

Question 11

What can be given to prevent SSRI induced sexual dysfunction?

Answer 11

Cyproheptadine (5HT2 blocker)

Question 12

3 symptoms of Serotonin Syndrome

Answer 12

Tremor
Hyperthermia
CVS collapse

Question 13

Name an NARI

Answer 13

Reboxetine

Question 14

NARI adverse effects

Answer 14

Anticholinergic
- Dry mouth, constipation

Insomnia

Question 15

Name 2 SNRIs

Answer 15

Duloxetine, venlafaxine

Question 16

Other antidepressants + their class

Answer 16

Mirtazapine - NaSSA
Bupropion - NDRI
Agomelatine - Melatonin MT1, MT2 receptor agonist
Ketamine - Glutamate NMDA receptor antagonist
Vortioxetine - Multimodal at various HT receptors