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Antidepressants Flashcards

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1
Q

What are the SSRI medications

A
  1. Fluoxetine
  2. Paroxetine
  3. Sertraline
  4. Citalopram
  5. Escitalopram
  6. Fluvoxamine
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2
Q

What is the MOA of SSRI

A

selectively block neuronal reuptake of seratonin
this increases the synaptic concentration and increases the activation of post-synaptic 5-HT receptors

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3
Q

What is the use of Fluoxetine

A

Major depression
Bipolar Disorder
OCD
Panic Disorder
Bulemia

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4
Q

What are the SE of Fluoxetine

A

sexual dysfunction
Nausea
Headache
Nervousness
Insomnia
Anxiety
Weight gain
Serotonin Syndrome

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5
Q

What are the uses for Paroxetine

A

Major Depression

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6
Q

What is the MOA of Paroxetine

A

selectively block neuronal reuptake of serotonin- increases activation of post synaptic 5-HT receptors

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7
Q

what are the SE of Paroxetine

A

Nausea
Insomnia
HA
Nervousness
weight gain
sexual dysfunction
hyponatremia
GI bleed

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8
Q

What are the uses of Sertraline

A

Major Depression

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9
Q

What is the MOA for Sertraline

A

selectively block neuronal reuptake of serotonin - increase activation of post synapti 5-HT receptors

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10
Q

What are the SE of Sertraline

A

Nausea, Insomnia, HA, nervousness, Weight gain, Sexual dysfunction, hypnatremia, GI bleed

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11
Q

what are the uses of Citalopram

A

Major Depression

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12
Q

What is the MOA of Citalopram

A

selectively block neuronal re-uptake of serotonin- increase post synaptic serotonin receptors

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13
Q

What are the SE of Citalopram

A

Nausea, Insomnia, Nervousness, Weight gain, Sexual dysfunction, GI bleed, Hyponatremia

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14
Q

What is the use of Escitalopram

A

Major Depression

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15
Q

What is the MOA of Escitalopram

A

selectively block the reuptake of serontonin - increase activation of post synaptic serotonin receptors

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16
Q

what are the SE of Escitalopram

A

Nausea, insomnia, Nervousness, Headache, weight gain, sexual dysfunction, hyponatremia, Gi bleed

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17
Q

What are the uses of Fluvoxamine

A

Off label for Major Depression

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18
Q

What is the MOA of Fluvoxamine

A

selectively block neuronal reuptake of serotonin - increase activation of post synaptic serotonin receptors

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19
Q

what are the SE of Fluvoxamine

A

nausea, insomnia, headache, nervousness, sexual dysfunction, hyponatremia, GI bleed, weight gain

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20
Q

What are the SNRI’s

A

Duloxetine
Venlafaxine
Desvenlafaxine

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21
Q

What is the use of Duloxetine

A

Major Depression
GAD
Chronic pain

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22
Q

What is the MOA of Duloxetine

A

block neuronal reuptake of serotonin and norepinephrine with minimal affect on other transmitters or receptors

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23
Q

What are the SE of Duloxetine

A

Nausea, HA, Anorexia, nervousness, sweating, somnolence, and insomnia
dose-related weight loss
diastolic hyptensions

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24
Q

what are contraindications for Duloxetine

A

combo use with MAOI’s
neonatal withdrawal syndrome and regular withdrawal syndrome

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25
Q

what are the uses for Venlafaxine

A

1st for major depression
GAD
Social Anxiety
Panic Disorder
Depressive episodes for Bipolar disorder

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26
Q

what is the MOA of Venlafaxine

A

Block neuronal reuptake of 5HT and NE

27
Q

what are the SE of Venlafaxine

A

Nausea, HA, anorexia, nervousness, sweating, insomnia
dose-related weight loss
diastolic hypertension

28
Q

what are contraindications for Venlafaxine

A

Combo use with MOAI’s
neonatal/withdrawl syndromes

29
Q

what are the uses for desvenlafaxine

A

major depression
off label for panic disorder, social phobias, GAD and chronic pain

30
Q

What is the MOA of Desvenlafaxine

A

Blocks neuronal reuptake of 5HT and NE

31
Q

what are the SE of desvenlafaxine

A

Nausea, HA, Anorexia, nervousness, sweating, insomnia
Dose-related weight loss
Diastoic hypertension

32
Q

What are contraindications for Desvenlafaxine

A

Combo use with MAOI’s
neonatal/withdrawal syndromes

33
Q

What are the TCA’s

A

Amytriptyline
Imiprimine
Nortriptyline
Despiramine

34
Q

What are the uses of Amytriptyline

A

second line for Major Depression
fibromyalgia, neuroleptic pain, chronic insomnia, ADHD, panic disorder and OCD

35
Q

What is the MOA of Amytriptyline

A

Non-selective: blocks neuronal reuptake of NE and 5HT
also cause direct blockade for histamine and Ach

36
Q

what are the SE of Amytriptyline

A

orthostatic hyptension, sedation, dry mouth, blurred vision, photophobia, constipation, urinary retention, tachycardia

37
Q

What are the risks of amytriptyline

A

seratonin syndrome
cardiotoxicity - increase seizure risk
OD = life threatening

38
Q

What are Drug interactions with TCAs

A

MAOIs
sympathomimetics
anticholinergics
CNS depressants

39
Q

What are the uses for Impiramine

A

Second line for Major depression
fibromyalgia, neuroletpic pain, chronic insomnia, ADHD, panic disorder, OCD

40
Q

What is the MOA of imipramine

A

non-selective: block neuronal reuptake of NE and 5HT
also cause direct blockade of receptors for histamine and Ach

41
Q

What are the SE of Imiprimine

A

orthostatic hypotension, sedation, cholonergic effects, tachycardia

42
Q

What are risks of Imiprimine

A

Seratonin syndrome
cardiotoxicity - increase seizure risk
OD = life threatening

43
Q

What are the uses of Norytriptyline

A

secondary TCA
second line for Major depression
fibromyalgia, neuroleptic pain, chronic insomnia, ADHD, OCD, panic disorder

44
Q

What is the MOA of Norytriptyline

A

Selective: Block neuronal reuptake of NE NOT 5HT
also causes direct blockake of histamine and Ach receptors

45
Q

What are the SE of Norytriptyline

A

orthostatic hypotension, sedation, cholinergic effects, tachycardia

46
Q

What are the uses of Despiramine

A

secondary TCA
secondary for Major depresion
also used for fibromyalgia, euroleptic pain, chronic insomnia, ADHD, OCD and panic disorder

47
Q

what is the MOA of Despiramine

A

selective: blocks neuronal reuptake of NE NOT 5HT
also causes direct blockade of histamine and Ach receptors

48
Q

what are the SE of Despiramine

A

orthostatic hypotension, sedation, cholinergic effects, tachycardia

49
Q

what are risks for Norytriptyline and Despiramine

A

Seratonin syndrome
Cardiotoxicity - increase seizure risk
OD = life threatening

50
Q

What are the MAOI medications

A

Selegiline
Phenelzine

51
Q

what are the uses of Selegiline

A

LAST RESORT DRUG

52
Q

what is the MOA of Selegiline

A

irreversible non-selective MAOI afffecting NE, DA and 5HT.

53
Q

what are the AE of Selegiline

A

Food and other drug interactions: Tryamine (cheeses), sympathomimetic drugs
weight gain
orthostatic hypotension
insomnia
sexual dysfunction
narrow TI

54
Q

What is the use of Phenelzine

A

Last resort drugs

55
Q
A
56
Q

what is the MOA of Phenelzine

A

irreversible non-selective affecting NE, DA and 5HT

57
Q

What are AE of Phenelzine

A

tyramine interaction, sympathomimetic drugs, weight gain, orthostatic hypotension, insomnia, sexual dysfunction, narrow TI
Hepatotoxicity

58
Q

What are the Atypical antidepressants medications

A

Bupropion
Mirtazapine
Trazadone

59
Q

what is the MOA of Buproprion

A

does not have direct serotonergic effects

60
Q

what are SE of bupropion

A

may cause anxiety
does not have sexual dysfunction affects

61
Q

what is the MOA of Mirtazapine

A

unique presynaptic MDA increase release of NE and 5HT
antihistamine effects

62
Q

what are the SE of mirtazapine

A

Weight gain
less sexual dysfunction

63
Q

what are the SE of Trazadone

A

too sedating to tolerate in full antidepressant dose
commonly used in lower doses as hypnotic

Psych Clinical (5 decks)

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