Antidepressants Flashcards
SSRI
Antidepressant
First Line
SNRIs
Antidepressant
First Line
Bupropion
Antidepressant
First Line
Mirtazapine
Antidepressant
First Line
TCAs
Antidepressant
Second Line/Alternative Agent
MAOIs
Antidepressant
Second Line/Alternative Agent
Major Depressive Disorder
5+ for atleast 2 weeks
- DEPRESSED MOOD
- DIMINISHED INTEREST/PLEASURE (anhedonia)
- significant weight loss/gain
- insomnia or hypersomnia
- psychomotor agitation/retardation
- fatigue or loss of energy
- feelings of worthlessness or excessive guilt
- diminished ability to think or concentrate; indecisivenss
- recurrent thoughts of death; suicidal ideation or attempt
The Monoamine Hypothesis
- depressed mood results from decreased monoamine neurotransmission
- major classes of clinically useful drugs INCREASE monoamine neurotransmission by LIMITING THE REUPTAKE OF MONOAMINE NEUROTRANSMITTERS or by preventing their breakdown
Process of release/effect of NT
Neurotransmitters:
- synthesized from amino acid precursors in specific neurons
- packaged into vesicles
- released in response to stimulus
- bind postsynaptic receptors
- subject to reuptake by presynaptic transporters
Catecholamines from Tyrosine
Monoamine Neurotransmitters
- epinephrine
- dopamine
- norepinephrine
Tryptamines from Tryptophan
Monoamine Neurotransmitter
- serotonin
Reserpine
inhibits VMAT
SSRI Site of Action
- block reuptake of serotonin
- serotonin left in extracellular space left to interact with receptors for longer period of time
SNRI Site of Action
- block reuptake of serotonin and norepinephrine
- same as TCAs
- serotonin and norepi left in extracellular space left to interact with receptors for a longer period of time
- ** MORE SELECTIVE THAT TCAs***
TCAs Site of Action
- block reuptake of serotonin and norepinephrine
- same as SNRIs
- serotonin and norepi left in extracellular space left to interact with receptors for a longer period of time
- ** INTERACT WITH A WHOLE BUNCH OF OTHER RECEPTORS AS WELL ***
MAOIs Site of Action
- prevent breakdown of monoamines in presynaptic cell
- inhibit MAO; prevents breakdown of NT, increasing amount in extracellular space
- ACT INTRACELLULARLY
Bupropion Site of Action
- blocks reuptake of DOPAMINE and norepinephrine
- acts on dopaminergic neuron
Mirtazapine Site of Action
- blocks presynaptic a2 receptors and some 5-HT2/3 receptors
- antagonist of presynaptic a2 autoreceptor, which ENHANCES RELEASE OF NE and 5-HT
- block binding of NT to presynaptic recpetor
Limitations to Monoamine Hypothesis
- clinically useful antidepressants act rapidly at pharmacologic sites of action, yet clinical effects require 3+ weeks of therapy
- while reserpine rapidly depletes neurotransmitter, several weeks of treatment are required to induce depression
Major Antidepressant Site of Action Targets
Neurotransmitter reuptake transporters
* activity limited by reuptake rate*
Autoreceptors
- found on presynaptic cell
- respond to level of neurotransmitter
- when reuptake is blocked, elevated NT in synapse leads to down-regulation of synthesis and release of additional NT
- upon chronic use, autoreceptors may be down regulated, thereby relieving inhibition of NT synthesis and release, and enhancement of neurotransmission
- receptors constantly bound to ligand, receptor downregulated and removed from cell surface
- MAY ACCOUNT FOR LIMITATIONS OF HYPOTHESIS
SSRI uses
- MAJOR DEPRESSION
- anxiety disorder
- OCD
- PTSD
- PMDD