Antidepressants

Question 1

Drug that blocks epinephrine, dopamine,serotonin that leads to depression

Answer 1

MAOI - Monoamine Oxidase Inhibitors

“Help to keep you happy”

Question 2

Example of MAOI

“Remember PITS”

Answer 2

Phenelzine
Isocarboxazid
Tranylcypromine
Selegiline

Question 3

Side effects of MAOI

Answer 3

Anticholinergic +

Insomnia

Question 4

Diet restriction for MAOI

Answer 4

Tyramine

Question 5

What happens if patient ate tyramine containing diet?

Answer 5

Hypertensive crisis

Question 6

Example of diet with tyramine

Answer 6

NO to Preserved salted meat
NO to Grains with active yeast
NO to BAR (Banana,Avocado,Raisins)
NO to cheese except cottage
NO to coffee, tea, chocolate, soy sauce

Question 7

Signs of hypertensive crisis

Answer 7

Headache
Increase BP
Palpitations

Question 8

How many weeks for MAOI to work?

Answer 8

4-6 weeks

Question 9

MAOI is contraindicated to:

Answer 9

Other antidepressant drugs such as SSRI and Tricyclics

Question 10

3 types of antidepressants

Answer 10

MAOI
SSRI
Tricyclics

Question 11

Type of antidepressant that inhibit the reuptake of serotonin

Answer 11

SSRI - selective serotonin reuptake inhibitor

Question 12

Example of SSRI

Answer 12

Setraline
Flouxetine
Paroxetin
Citalopram

Question 13

What are the two SSRI drugs that can cause suicidal ideation in children and insomnia?

Answer 13

Flouxetine

Paroxetin

Question 14

SSRI drug that does not cause insomia, can be given at bedtime

Answer 14

Sertraline

Question 15

SSRI drug that is very sedating and patient should avoid driving

Answer 15

Citalopram

Question 16

How many days to wait if to switch antidepressant from MAOI to SSRI or vise versa?

Answer 16

14 days

Question 17

Contraindicated herbal medication specific for SSRI

Answer 17

St. John’s Wort - may cause serotonin overload or serotonin syndrome

Question 18

Signs of too much SSRI

Answer 18

Sweating
Apprehensive
Dizziness
Headache

“SADHead”

Question 19

Type of antidepressant that increase serotonin and norepinephrine

Answer 19

Tricyclics

Question 20

Example of Tricyclics

Answer 20

Amitriptyline
Nortriptyline
Desipramine
Imipramine
Clomipramine

“ Ends in TYLINE, PRAMINE”

Question 21

Tricyclic drug given for OCD

Answer 21

Clomipramine

Question 22

What are other indication of Tricyclic drugs for children?

Answer 22

Enuresis

Question 23

Side effect of SSRI

Answer 23

Anticholinergic +

Risk for suicide

Question 24

What cardiac changes to monitor for Tricyclics?

Answer 24

Tachycardia
Orthostatic hypotension
EKG long QT intervals

Question 25

Best time to give Tricyclics

Answer 25

Bedtime

Question 26

Teaching points for Tricyclics, contraindicated drink?

Answer 26

Alcohol

Question 27

How many weeks for Tricyclics to work?

Answer 27

6 weeks

Question 28

What is the anibiotic contraindicated to SSRI?

Answer 28

Azithromycin

SSRI + azithromycin will cause dysrhythmias, long QT interval