Antidepressants Flashcards

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1
Q

Drug that blocks epinephrine, dopamine,serotonin that leads to depression

A

MAOI - Monoamine Oxidase Inhibitors

“Help to keep you happy”

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2
Q

Example of MAOI

“Remember PITS”

A

Phenelzine
Isocarboxazid
Tranylcypromine
Selegiline

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3
Q

Side effects of MAOI

A

Anticholinergic +

Insomnia

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4
Q

Diet restriction for MAOI

A

Tyramine

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5
Q

What happens if patient ate tyramine containing diet?

A

Hypertensive crisis

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6
Q

Example of diet with tyramine

A
NO to Preserved salted meat
NO to Grains with active yeast
NO to BAR (Banana,Avocado,Raisins)
NO to cheese except cottage
NO to coffee, tea, chocolate, soy sauce
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7
Q

Signs of hypertensive crisis

A

Headache
Increase BP
Palpitations

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8
Q

How many weeks for MAOI to work?

A

4-6 weeks

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9
Q

MAOI is contraindicated to:

A

Other antidepressant drugs such as SSRI and Tricyclics

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10
Q

3 types of antidepressants

A

MAOI
SSRI
Tricyclics

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11
Q

Type of antidepressant that inhibit the reuptake of serotonin

A

SSRI - selective serotonin reuptake inhibitor

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12
Q

Example of SSRI

A

Setraline
Flouxetine
Paroxetin
Citalopram

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13
Q

What are the two SSRI drugs that can cause suicidal ideation in children and insomnia?

A

Flouxetine

Paroxetin

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14
Q

SSRI drug that does not cause insomia, can be given at bedtime

A

Sertraline

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15
Q

SSRI drug that is very sedating and patient should avoid driving

A

Citalopram

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16
Q

How many days to wait if to switch antidepressant from MAOI to SSRI or vise versa?

A

14 days

17
Q

Contraindicated herbal medication specific for SSRI

A

St. John’s Wort - may cause serotonin overload or serotonin syndrome

18
Q

Signs of too much SSRI

A

Sweating
Apprehensive
Dizziness
Headache

“SADHead”

19
Q

Type of antidepressant that increase serotonin and norepinephrine

A

Tricyclics

20
Q

Example of Tricyclics

A
Amitriptyline
Nortriptyline
Desipramine
Imipramine
Clomipramine

“ Ends in TYLINE, PRAMINE”

21
Q

Tricyclic drug given for OCD

A

Clomipramine

22
Q

What are other indication of Tricyclic drugs for children?

A

Enuresis

23
Q

Side effect of SSRI

A

Anticholinergic +

Risk for suicide

24
Q

What cardiac changes to monitor for Tricyclics?

A

Tachycardia
Orthostatic hypotension
EKG long QT intervals

25
Q

Best time to give Tricyclics

A

Bedtime

26
Q

Teaching points for Tricyclics, contraindicated drink?

A

Alcohol

27
Q

How many weeks for Tricyclics to work?

A

6 weeks

28
Q

What is the anibiotic contraindicated to SSRI?

A

Azithromycin

SSRI + azithromycin will cause dysrhythmias, long QT interval