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Week 1 > Antidepressant drugs > Flashcards

Antidepressant drugs Flashcards

1
Q

How do MAOIs work?

A

Inhibit MAO enzymes which breakdown noradrenaline, serotonin and dopamine

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2
Q

Name 3 MAOIs

A

Phenelzine
Selegiline
Tranylcypromine

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3
Q

Why should people on MAOIs not eat food high in tyramine?

A

May cause hypertensive crisis

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4
Q

Why should MAOIs not be used in combination with other antidepressants?

A

Increase serotonin levels to dangerous levels causing confusion, hypertension, tremor, coma and death
==> Neuropathic malignant syndrome

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5
Q

Name a Reversible MAO Type A Inhibitor (RIMA)

A

Moclobemide

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6
Q

What is the mechanism of action of tricyclics?

A

Inhibit re-uptake of noradrenaline and serotonin by blocking transporters responsible for the re-uptake

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7
Q

What is one of the major contraindications for tricyclics?

A

Patients with cardiovascular disease as they increase the risk of arrhythmias

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8
Q

Name 5 common tricyclics

A 
Amitriptyline
Clomipramine
Lofepramine 
Imipramine
Nortriptyline
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9
Q

Name a drug that is similar in action to tricyclics

A

Trazodone

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10
Q

What are the concerns with prescribing tricyclics?

A

Can be very dangerous in overdose so need to be careful how much is prescribed to patients with sucicidal ideation

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11
Q

What is the mechanism of action SSRIs?

A

Limit the reabsorption of serotonin (and NA and dopamine)

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12
Q

What is the major side effect of citalopram?

A

QT prolongation

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13
Q

Name 2 SNRIs

A

Duloxetine

Venlafaxine

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14
Q

Name an alpha 2 adrenoreceptor antagonist used as an anti-depressant

A

Mirtazapine

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15
Q

Name an antipsychotic that can be used as an antidepressant

A

Risperidone

Lithium

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16
Q

Name three antidepressants used for neuropathic pain

A

Amitriptyline
Nortitriptyline
Duloxetine

17
Q

What are the side effects of tricyclics?

A

Arrhythmias

Anti-muscarinic effects

18
Q

What are the side effects of SSRIs?

A 
Loss of libido
QT prolongation 
Bleeding 
Suicide 
Epilepsy (reduced fit threshold)
19
Q

Name 5 SSRIs

A 
Citalopram 
Sertraline 
Fluoxedtime 
Escitalopram 
Paroxetine
20
Q

Name an antidepressant used for diabetic neuropathy

A

Duloxetine

21
Q

What is the arrthymia called that is caused by QT prolongation?

A

Torsades de pointes

22
Q

Who are at risk of QT prolongation?

A

Elderly
Women
CVD patients
Psychiatric patients

Week 1 (6 decks)

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