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Pharm 1 > Anticonvulsants > Flashcards

Anticonvulsants Flashcards

1
Q

Carbamazepine

A

Na channel blocker, inhibits high-frequency, repetitive firing
Partial/tonic-clonic seizure

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2
Q

Carbamazepine

A

Na channel blocker, inhibits high-frequency, repetitive firing
Partial/tonic-clonic seizure

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3
Q

Phenytoin

A 
Prolongs inactivation of Na channels, inhibits rapid firing nuerons
Partial Seizures
Generalized tonic-clonic
NOT Absence
Zero Order
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4
Q

Phenobarbital

A

Enhancement of GABA activity (increase inhibitory pathways)

Partial/tonic-clonic

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5
Q

Valproic Acid

A 
na/ca channel blocker
2nd choice for absence
tonic-clonic
myoclonic
Weight gain
Hepatotoxicity (monitor liver enzymes)
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6
Q

Ethosuximide

A

Blockade of thalamic t-type ca current, ‘pacemaker of thalmaic neurons for treatment of absence seizure, Na channel blocker

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7
Q

Diazepam

A

Enhancement of GABA activity (increase inhibitory pathways)

Tolerance is common

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8
Q

Partial/Simple Seizure

A

20-90s, NO loss of conscioiusness

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9
Q

Partial/Complex Seizure

A
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10
Q

Generalized/Tonic-Clonic Seizure

A

Initial tonic rigidity (15-30s), Tremor, Clonic jerking (60-120s), Loss of consciousness

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11
Q

Generalized/Absence Seizure

A

THALMUS started, Sudden onset, 10-30s, loss of awareness, 3Hz spike in EEG

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12
Q

Generalized/Myoclonic Seizure

A

Brief spasm, often benign

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13
Q

Phenytoin

A 
Prolongs inactivation of Na channels, inhibits rapid firing nuerons
Partial Seizures
Generalized tonic-clonic
NOT Absence
Zero Order
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14
Q

Phenobarbital

A

Enhancement of GABA activity (increase inhibitory pathways)

Partial/tonic-clonic

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15
Q

Valproic Acid

A 
na/ca channel blocker
2nd choice for absence
tonic-clonic
myoclonic
Weight gain
Hepatotoxicity (monitor liver enzymes)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Ethosuximide

A

Blockade of thalamic t-type ca current, ‘pacemaker of thalmaic neurons for treatment of absence seizure, Na channel blocker

17
Q

Diazepam

A

Enhancement of GABA activity (increase inhibitory pathways)

Tolerance is common

18
Q

Partial/Simple Seizure

A

20-90s, NO loss of conscioiusness

19
Q

Partial/Complex Seizure

A
20
Q

Generalized/Tonic-Clonic Seizure

A

Initial tonic rigidity (15-30s), Tremor, Clonic jerking (60-120s), Loss of consciousness

21
Q

Generalized/Absence Seizure

A

THALMUS started, Sudden onset, 10-30s, loss of awareness, 3Hz spike in EEG

22
Q

Generalized/Myoclonic Seizure

A

Brief spasm, often benign

Pharm 1 (15 decks)

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