Anticongenes

Question 1

Rb

Answer 1

Retinoblastoma
two-hit hypothesis of Knudson
familial forms: one inherited, one somatic
sporadic nonfamilial: both somatic

Question 2

P53

Answer 2

Li-Fraumeni syndrome

Question 3

BRCA-1 & BRCA-2

Answer 3

breast and ovarian cancers

Question 4

BRCA1 and BRCA2 (BReast CAncer genes 1 and 2) are the best-known
genes linked to

Answer 4

breast cancer risk.

Question 5

BRCA1 and BRCA2 are proteins that help repair

Answer 5

damaged DNA and play a role in ensuring the stability of each cell’s genetic material

Question 6

Neoplasia (“new growth”)

Answer 6

uncontrolled, disorderly proliferation of cells resulting in a benign or malignant growth

Question 7

Neoplasm

Answer 7

abnormal mass with growth that is not coordinated with the normal tissue and which persists in the same manner after cessation of the stimuli which evoked the change

Question 8

Tumor:

Answer 8

swelling (inflammation

Question 9

Oncology:

Answer 9

study of tumors (neoplasms

Question 10

Cancer (“crab”)

Answer 10

malignant tumors