Anticoagulants, antiplatelets and thrombolytics

Question 1

Give examples of drugs which are derivatives of tPA?
- Colloquially known as ‘clot busters’

Answer 1

• Ateplase
• Reteplase
• Tenectaplase

Question 2

What drug has a similar mechanism of action to tPA and is derived from Beta hemolytic bacteria proteins?

Answer 2

Streptokinase

Question 3

What is the MOA of tPA?

Answer 3

Degrades plasminogen into plasmin
- Plasmin degrades fibrin

Question 4

Give examples of LMWH?

Answer 4

• Enoxaparin
• Dalteparin

Question 5

Give examples of DOACs

Answer 5

• Apixaban
• Rivaroxaban

Question 6

Direct thrombin inhibitor examples

Answer 6

• Bivalirudin
• Dabigatran
• Argatroban

Question 7

What is fondaparinux similar to?

Answer 7

Basically synthetic derivative of LMWH

Question 8

What is unfractionated heparin prescribed as?

Answer 8

Unfractionated heparin (used in PCI)

Question 9

What are examples of GpIIb/IIa inhibitors?
- use as bailout in STEMI PCI

Answer 9

• Abciximab
• Eptifibatide
• Tirofiban

Question 10

What do Prasugrel and Ticagrelor act on?

Answer 10

P2Y12