Anticoagulants Flashcards
mainly for prevention and tx of VENOUS Thrombosis
Anticoagulants
MOA Anticoag
Inhibit formation of Fibrin Clots
MOA warfarin
Impairs post translational modification of Factors 2,7,9,10
Anticoag that inhibits Vit K Epoxide reductase
Warfarin
This drug SE: Drug induced Skin Necrosis,
With Narrow therapeutic window
Warfarin
MOA Heparin
Activates Anti - Thrombin III/AT III
Onset:
Heparin
Warfarin
Rapid
Slow
Lab for Aspirin monitoring
BT
Causes severe infusion reaction when administered too fast
Dyspnea, Chest and Back pain
Vitamin K
Anticoag that bind and potentiates effect of ATIII on FACTOR Xa
(more selective)
EnoXAparin
Advantage Enoxaparin vs Heparin
Less risk of thrombocytopenia
does not require monitoring with PTT
Monitoring for Warfarin
PTT
For patient with aspirin allergy
Clopidogrel
Irreversibly inhibits binding of ADB to platelet receptors
Clopidogrel
antiplatelet
Inhibits PDE III- inc CAMP
Can also cause vasodilation
Dipyridamole
Dipyridamole CI in
Heart failure
Thrombolytic drug that has a SE of Cerebral hemorrhage
Alteplase (streptokinase)
converts plasminogen to plasmin
degrades fibrin and fibrinogen
Anticoag for patient with Heparin induced thrombocytopenia
Lepirudin
binds to thrombin’s active site and inhibits its enzymatic action
Inc Factor 8 activity of patient with mild Hemophilia A or von willebrand disease
Desmopressin
Vasopressin V2 receptor agonist/ ADH agonist
antiplatelet
interferes with GP2b/3a binding to fibrinogen
Abciximab
used during PCI to prevent Thrombosis
Used for anemia assoc with Chronic Renal Failure
Epoietin Alfa
