Anticoagulants

Question 1

Factor I (Made)

Answer 1

Fibrinogen (Liver) - “Threads”

Question 2

Factor II (Made)

Answer 2

Prothrombin (Liver) “Activator”

Question 3

Factor III (Made)

Answer 3

Tissue Factor or Thromboplastin (vascular walls)

Question 4

Factor IV (Made)

Answer 4

Calcium (Diet)

Question 5

Factor V (Made)

Answer 5

Proaccelerin (liver)

Question 6

Factor VI (Made)

Answer 6

NOT ASSIGNED

Question 7

Factor VII (Made)

Answer 7

Proconvertin (liver) - Has shortest half-life

Question 8

Factor VIII (Made)

Answer 8

Antihemophilic Factor (Liver)

Question 9

VIII:vWF

Answer 9

Factor 8 with von Willibrands Factor

Question 10

von Willibrands Factor is Made in

Answer 10

Vascular Endothelium/Endothelial Cells

Question 11

Factor IX

Answer 11

Christmas Factor (Liver)

Question 12

Factor X

Answer 12

Stuart-Prower Factor (liver)

Question 13

Factor XI

Answer 13

Plasma Thromboplastin Antecedent (Liver)

Question 14

Factor XII

Answer 14

Hageman Factor (Liver)

Question 15

Factor XIII

Answer 15

Fibrin Stabilizing Factor (LIver) - “GLUE”

Question 16

Which factors are Vitamin K dependent?

Answer 16

II, VII, IX, X (2, 7, 9, 10)

Question 17

Zymogen

Answer 17

Compounds that are inactivated and become activated. All the factors in the clotting cascade.

Question 18

The Zymogens of the Intrinsic Pathway include:

Answer 18

XII, XI, IX, VIII:vWF, IV (12, 11, 9, 8, 4 and vWF) $12/11.98

Question 19

The Zymogens of the Extrinsic Pathway include:

Answer 19

VII, III, IV (7, 3, 4) - 37cents

Question 20

The Zymogens of the Common Pathway include:

Answer 20

I, II, V, X, XIII (1, 2, 5, 10, 13); There is ONE (I) common pathway to form CLOTS, a five letter word, (V). 5 x 2(II) = 10 (X). And 13 because that’s a lucky number!

Question 21

The five natural Anticoagulants are:

Answer 21

Prostacyclin
Antithrombin
Heparan Sulfate Proteoglycans
Protein C
Tissue Factor Pathway Inhibitor

Question 22

Prostacyclin

Answer 22

Is an Arachidonic acid metabolite
made by endothelial cels
Inhibit platelet aggregation

Question 23

Antithrombin III

Answer 23

Plasma protein, Inhibits coag factors of the intrinsic and common pathways

Question 24

Heparan Sulfate Proteoglycans

Answer 24

Made by endothelial cells

Stimulate Antithrombin

Question 25

Protein C

Answer 25

Activated by Thrombin
Degrades Cofactors Va and VIIIa (5&8)
Diminishes Activation of Prothrombin (II) and Factor X.

Question 26

Tissue Factor Pathway Inhibitor

Answer 26

Plasma lipoprotein
Binds to Xa
the Xa-TFPI inhibits factor VIIa

Question 27

Mnemonic for the Common pathway

Answer 27

The final common pathway can be purchased at the FIVE (V) and DIME (X) for ONE (I) or TWO (II) dollars on the 13th (XIII) of the month) - (10, 5, 2, 1 and 13)

Question 28

Factor IIa (Thrombin) Activates which cofactors

Answer 28

V, VII, VIII, XI, XIII (5, 8, 7, 11 and 13)