Anticoagulants

Question 1

Clexane is?

Answer 1

enoxaparin

Question 2

LMWH acts on which factor?

Answer 2

Factor Xa

Question 3

Warfarin acts on which factors?

Answer 3

2 (prothrombin),7,9,10

Protein C and S

Question 4

DOACcs act on which factor?

Answer 4

Xa

Question 5

Contraindications for LMWH

Answer 5

Active bleeding
Acquired bleeding disorder
Concurent use of another anti coag
LP / epidural / spinal in last 4hrs or expected in next 12

Question 6

Monitoring when on LMWH

Answer 6

Platlets
Renal function
Serum potassium

Question 7

Serious SE of LMWH

Answer 7

Heparin induced thrombocytopenia

Question 8

INR target if recurrent VTE/PE when anticoagulated

Answer 8

3.5

Question 9

Usual INR target for everyone except those who have had recurrent VTE/PE when anticoagulated

Answer 9

2.5 (2-3)

Question 10

INR >8 / >5 if elderly or high risk of bleeding treatment

Answer 10

Vit K 2mg Oral

Question 11

Minor bleed and INR >5 treatment

Answer 11

Vit K 2mg IV

Question 12

Major bleeding on warfarin treatment

Answer 12

5mg Vit K IV

Question 13

What denotes a stable INR

Answer 13

<4 and regular checks

Question 14

INR 5-8 (no active bleeding) treat with ?

Answer 14

withholding 1 or 2 doses of warfarin

Question 15

How are LMWH dosed?

Answer 15

By weight - units/ kg