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Drug Mech Test 3 > Anticoagulants > Flashcards

Anticoagulants Flashcards

1
Q

ITI or DTI?

Heparin

A

Indirect thrombin inhibitors

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2
Q

ITI or DTI?

Dabigatran

A

Direct thrombin inhibitor

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3
Q

What drug class is Fondaparinux in?

A

Indirect Factor Xa inhibitors

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4
Q

What drug class is Rivaroxaban in?

A

Direct Factor Xa inhibitors

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5
Q

What drug class is Warfarin in?

A

Vitamin K Antagonists

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6
Q

Which two genes are polymorphisms common in with Warfarin?

A

CYP2C9 and VKORC1

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7
Q

Fibrinolytic or Antifibrinolytic?

Streptokinase

A

Fibrinolytic

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8
Q

Streptokinase is a protein derived from which type of bacteria?

A

Streptococci

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9
Q

Fibrinolytic or Antifibrinolytic?

Urokinase

A

Fibrinolytic

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10
Q

Urokinase is a human enzyme synthesized by what organ?

A

kidney

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11
Q

Urokinase directly converts plasminogen to active ________

A

plasmin

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12
Q

Where is plasmin formed?

A

inside the thrombus

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13
Q

What are the plasminogen activators (t-PA)?

A

Alteplase
Reteplase
Tenecteplase

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14
Q

Plasminogen can be activated by….?

A

t-PA

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15
Q

What is aspirin?

A

Antiplatelet agent

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16
Q

What drug class is clopidogrel in?

A

thienopyridine

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17
Q

What bioactivates clopidogrel?

A

CYP2C19

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18
Q

Which class of drug can reduce the enzymatic activity of CYP2C19?

A

Proton Pump Inhibitors (PPIs)

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19
Q

What is the best PPI a patient on clopidogrel can use?

A

pantoprazole

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20
Q

What drug class is Ticagrelor in?

A

Cyclopentrltriazolopyrimidine

21
Q

Ticagrelor is an inhibitor of…?

22
Q

Name the GP IIb/IIIa receptor antagonists

A

Abciximab
Eptifibatide
Tirofiban

23
Q

What drug class is Vorapaxar in?

A

PAR-1 antagonists

24
Q

What is dypyridamole?

A

antiplatelet

25
What is the antidote for heparin?
protamine sulfate
26
Is heparin strongly acidic or basic?
acidic
27
HMWH has a high affinity for binding to....?
antithrombin
28
HMWH inhibits blood coagulation by inhibiting both....?
thrombin and factor Xa
29
LMWH has an affinity for binding to....?
antithrombin but lower affinity that HMWH
30
LMWH inhibits...?
clotting factor Xa but has less effect on thrombin
31
Does Dabigatran have a shorter or longer half-life than Warfarin?
shorter
32
Which antiplatelet is a potent competitive and reversible DTI?
Dabigatran
33
Which drug is a synthetic analog of the pentasaccharide sequence of heparin?
Fondaparinux
34
Does Rivaroxaban have a shorter or longer half-life than warfarin?
shorter
35
The only common adverse effect of rivaroxaban is...?
bleeding
36
Which enantiomer of warfarin is more potent? R or S?
S-Warfarin is 3-5 times more potent than R-Warfarin
37
What increases the anticoagulant effect of warfarin by its effect on platelet function?
aspirin
38
What increases the anticoagulant effect of warfarin by inhibiting the activity of several clotting factors and directly prolonging the prothrombin time?
heparin
39
What increases the anticoagulant effect of warfarin by eliminating the bacterial microflora that produce vitamin K in the intestine, and also by directly inhibiting vitamin K epoxide reductase enzyme?
third generation cephalosporins
40
What increases the anticoagulant effect of warfarin by inhibiting the synthesis of clotting factors in the liver?
hepatic disease
41
What increases the anticoagulant effect of warfarin by increasing the turnover rate (degradation) of clotting factors?
Hyperthyroidism
42
What decreases the anticoagulant effect of warfarin by increasing the synthesis of clotting factors?
vitamin K
43
What decreases the anticoagulant effect of warfarin by increasing the concentration of clotting factors in the general circulation?
diuretics
44
What decreases the anticoagulant effect of warfarin by decreasing the turnover rate of clotting factors?
hypothyroidism
45
What can alter the anticoagulant effect of warfarin as a result of mutational change of vitamin K epoxide reducatase enzyme?
variations in the VKORC1 gene
46
Which t-PA has the longest half-life?
Tenecteplase
47
What drug is made from animal origin?
heparin
48
What are the anti-fibrinolytics?
Aminocaproic acid and | Tranexamic acid

Drug Mech Test 3 (3 decks)

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