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Pharmacology > Anticancer drugs > Flashcards

Anticancer drugs Flashcards

1
Q

Cytarabine

A

Pyramidine analogue antimetabolite; does not require folate for its activity; incorporates into DNA and leads to strand termination; S-phase specific

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2
Q

Gemcitabine

A

Pyrimidine analogue but not S-phase specific. Inhibits ribonucleotide reducatse?

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3
Q

Fludarabine

A

Deaminase-resistant purine analogue; inhibits DNA polymerase, Primase, Ligase and ribonucleotide reducatase; CLL

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4
Q

5-FU

A

Inhibits thymidylate synthetase; THF (Leucovorin) potentiates its toxicity

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Pharmacology (5 decks)

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