Anticancer Drug-Specific Toxicities

Question 1

Bleomycin

Answer 1

Pulmonary toxicity (pulmonary fibrosis), cutaneous toxicity

Question 2

Cisplatin

Answer 2

Nephotoxicity, ototoxicity, peripheral neuropathy (motor and sensory)

Question 3

cyclophosphamide, Ifosfamide

Answer 3

Hemorhhagic cystitis due to acrolein metabolite product

Question 4

Methotrexate

Answer 4

Renal toxicity, hepatotoxicity, bone marrow toxicity, repro problems

Question 5

Paclitaxel and Docletaxel

Answer 5

Peripheral neuropathy

Question 6

Vincristine

Answer 6

Neurotoxicity (peripheral neuropathy)

Question 7

Akylating Agents

Answer 7

Bone marrow, mucosal toxicity, nausea and vomiting, toxic effects on repro systems, increased leukemia risk

Question 8

Carmustine and Lomustine

Answer 8

Renal toxicity, pulmonary fibrosis

Question 9

Procarbazine

Answer 9

May cause leukemia

Question 10

Oxailplatin

Answer 10

Peripheral sensory neuropathy (cold induced)

Question 11

5-FU

Answer 11

Hand foot syndrome (erythema, sensitivity of palms and soles) Cardiac toxicity (acute chest pains)

Question 12

6-MP

Answer 12

hepatatoxicity in prolonged use

Question 13

Dactinomycin

Answer 13

hematopoietic suppression with pancytopenia

Question 14

Anthracyclines

Answer 14

Irreversible dose dependent cardio toxicity, alopecia. Dexrazoxane is a iron chelating agent that block formation of free radicals and protects against cardiotoxicity

Question 15

tamoxifen

Answer 15

hot flashes, hair loss, increased risk of endometrial cancer; increased risk of thromboembolic event.

Question 16

Etoposide and Teniposide

Answer 16

Does limiting myelosuppression

Question 17

Irinotecan and Topotecan

Answer 17

Severe neutropenia and severe diarrhea.