Antibotics Exam 3

Question 1

Minimal Inhibitory Concentration (MIC)

Answer 1

The minimum drug conc. at which the bacterial population is inhibited to prevent visual growth.

Question 2

Minimal Bactericidal Concentration (MBC)

Answer 2

The minimum drug conc. at which the bacterial population is killed.

Question 3

What antimicrobial is the most toxic to humans?

Answer 3

Natural antibiotics are more toxic and less effective. Synthetic are loss toxic and more effective.

Question 4

True or False? All antibiotics are antimicrobials, but not all antimicrobials are antibiotics.

Answer 4

True.

Question 5

Broad spectrum antibacterials are effective against…

List the examples.

Answer 5

Gram pos and Gram neg

tetracyclines, phenicols, fluroquinolones, 3rd and 4th generation cephalosporins.

Question 6

Glycopeptides and bacitracin are only effective against…

Answer 6

Gram pos bacteria

Question 7

Polymixins are effective against….

Answer 7

Only gram neg bacteria

Question 8

Aminoglycosides and sulfonamides are effective against…

Answer 8

Aerobic organisms

Question 9

Nitroimidazoles are effective against…

Answer 9

Anaerobes.

Question 10

What are the antibiotics classified into?

List them.

Answer 10

Function.

Inhibits cell wall synthesis, protein synthesis, membrane function, DNA/RNA synthesis, and various metabolic processes.

Question 11

What is beta-lactams classified into?

Answer 11

Inhibits cell wall synthesis

Question 12

List antibiotics that are beta-lactams

Answer 12

penicillin, cephalosporins, monobactams, carbapenems, glycopeptides, fosfomycins. Have to have a cell wall unlike Mycoplasma and Ureaplasma

Question 13

What 2 amino acids form the beta-lactam ring?

Answer 13

Valine and Cysteine.

Question 14

How do the Beta-lactams work?

Answer 14

BL ring binds to penicillin binding protein. Antibiotic binding to PBP inhibits their actions.