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Immunology > Antibody therapies > Flashcards

Antibody therapies Flashcards

1
Q

Target cell surface antigens

A 
BARNT:
Basiliximab (anti IL2R aka CD25)
Abatacept (anti-CTLA4-Ig; CTLA4/CD25 T cell + CD80/86 B cell system)
Rituximab (anti-CD20)
Natalizumab (anti-integrinalpha4)
Tocilizumab (anti-IL6R)
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2
Q

Target cytokines

A 
Infliximab, Adalimumab, Certolizumab, Golimumab (anti-TNFalpha)
Etanercept (anti-TNF)
Ustekinumab (anti-IL12 + 23)
Guselkumab (anti-IL23)
Secukinumab (anti-IL17)
Denosumab (anti-RANKL)
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3
Q

Inhibit calcineurin - IL-2 - T cell proliferation

A

CycT:
Calcineurin inhibitors:
Cyclosporin
Tacrolimus

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4
Q

JAK inhibitor

A

Tofacitinib

Jack is a right toff

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5
Q

PDE4 inhibitor

A

Apremilast

Pride after a fall

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6
Q

Basiliximab

A

anti-IL2R (CD25)

Harry Potter 2 = basilisk

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7
Q

Abatacept

A

(anti-CTLA4)
Ig fusion protein
CTLA4/CD25 T cell + CD80/86 B cell system
‘Looking for abata system’

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8
Q

Rituximab

A

anti-CD20

Tu Xs

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9
Q

Natalixumab

A

anti-integrin alpha 4

‘Natalixing you through’

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10
Q

Tocilizumab

A

anti-IL6R

Tick tock its 6 o clock

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11
Q

Infliximab

A

anti-TNFalpha

Alpha inflicts pain in the library

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12
Q

Adalibumab

A

anti-TNFalpha

Alpha inflicts pain in the library

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13
Q

Etanercept

A

anti-TNF (alpha + beta)

A tonne of TNF

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14
Q

Ustekinumab

A

anti-IL12 + IL23

U stick 12 and 23 together

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15
Q

Guselkumab

A

anti-IL23

23 Guseled 12

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16
Q

Secukinumab

A

anti-IL17

SEc SEventeen

17
Q

Denosumab

A

anti-RANKL

Deno is rank

Immunology (9 decks)

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