Antibodies Flashcards
1
Q
SLE autoantibodies
A
ANA
anti-dsDNA - always
anti-ENA (Ro, La, Sm, RNP, histone) - sometimes
2
Q
Types of ANA
A
- anti-dsDNA
- anti-ENA (anti-Ro, anti-La, anti-Sm, anti-RNP, anti-SCL70, anti-centromere)
- anti-cytoplasmic (anti-SRP, anti-Jo1)
3
Q
Types of ANCA
A
cANCA
pANCA
4
Q
anti-dsDNA
A
SLE
5
Q
anti-cytoplasmic
A
Myositis
incl. anti-Jo1, anti-SRP
6
Q
anti-Jo1
A
Dermatomyositis
7
Q
ANA
A
SLE, Sjogren’s, systemic sclerosis (limited CREST + diffuse), dermatomyositis, polymyositis
8
Q
anti-SRP
A
Polymyositis
9
Q
anti-Ro, anti-La
A
Sjogren’s (50%)
10
Q
anti-SCL70
anti-topoisomerase
A
Diffuse systemic sclerosis (diffuse scleroderma)
11
Q
anti-centromere
A
Limited systemic sclerosis (limited scleroderma) - CREST
12
Q
pANCA
anti-myeloperoxidase
A
Microscopic polyangiitis
Eosinophilic granulomatosis with polyangiitis (CS)
13
Q
cANCA
anti-proteinase3
A
Granulomatosis with polyangitis (Wegener’s)
14
Q
anti-desmoglein 1
A
Pemphigus foliaceus
15
Q
anti-desmoglein 3
A
Pemphigus vulgaris
