Antibody Qs 15-21

Question 1

You have purified some Fab from an IgG myeloma protein. Under appropriate conditions, you could use this Fab to generate antibodies to:

Answer 1

The idiotype of this myeloma.

Question 2

The Ig isotype which would be most important for neutralizing polio virus before it could infect intestinal cells would be:

Answer 2

Secretory IgA

Question 3

Which of the following changes to a serum IgM antibody molecule would definitely DECREASE its avidity?

Answer 3

Use limited enzyme digestion to make Fab fragments.

Question 4

IgA can be secreted from the body because it:

Answer 4

Binds poly-Ig receptor on mucosal epithelial cells.

Question 5

The ability to make antibody with the same antigen specificity but different Fc regions:

Answer 5

Increases the effector functions of Ig molecules.

Question 6

Allergy symptoms are produced when antigen binds to IgE on FcR on:

Answer 6

Mast cells.

Question 7

One amino acid difference in the Fc region of different human g chains is the epitope recognized by anti:

Answer 7

Allotype.