Antibody drugs Flashcards
infliximab
adalimumab
certilizumab
gloimumab
TNF-a inhibition
Infliximab-chimeric
Rest Humanized
Refractory-therapy for chronic inflammatory systemic diseases
Rheumatoid arthritis
Crohn disease, ulcerative colitis Ankylosing spondylitis
Psoriatic arthritis
can reactivation latent TB
also lead to drug induced lupus
Entanercept
not a monoclonal antibody. It is a decoy receptor produced by recombinant DNA that binds to TNF, reducing the effect of naturally present TNF; it is therefore a TNF inhibitor.
Refractory-therapy for chronic inflammatory systemic diseases
Rheumatoid arthritis
Crohn disease, ulcerative colitis Ankylosing spondylitis
Psoriatic arthritis
can reactivation latent TB
also lead to drug induced lupus
Rituximab
Chimeric
monoclonal antibody agains CD20
used for NH lymphoma, cll, its, Ra
increased rise for progressive multifocal leukoencephalopathy
Cetuximab
panitumumab
Monocolonal antibody against EGFR
stage IV colorectal ca wild types, and head and neck ca
Alemtuzumab
humanized
CD 52
Chronic lymphoid leukemia (CLL)
Escalation therapy of multiple sclerosis (see subsection “Disease-modifying therapy”, under Treatment section of multiple sclerosis)
natalizumab
alpha 4 intergin
Escalation therapy of multiple sclerosis (see subsection “Disease-modifying therapy”, under Treatment section of multiple sclerosis)
Crohn disease
omlizumab
IGE
used for severe allergic asthma
Abiciximab
antagonist of GP IIB/IIIa receptor
Muromonab CD3
mouse antibody
CD3 from T cells
dacizumab
basiliximab
Alpha chain (CD25 antigen) of the IL-2 receptor of T cells
Escalation therapy of multiple sclerosis
Formerly used for the prevention of kidney rejection post-transplantation (in combination with cyclosporine and glucocorticoids)
Trastuzumab
Her2/neu
Bevacizumab
VEGF
Neovascular age-related macular degeneration (off-label use in the US)
Colorectal cancer, renal cell carcinoma
do not give to people with GI bleeds
eculizumab
complement protein C5
PNH
Ustekinumab
Il 12, il23
Tocilizumab
il-6
