antibodies in rheumatology

Question 1

Anti-cyclic citrullinated peptide (anti-CCP)

Answer 1

Rheumatoid arthritis

Question 2

Anti-centromere

Answer 2

CREST syndrome (limited systemic sclerosis)

Question 3

Polymyositis / dermatomyositis

Answer 3

Anti-Jo-1 (one type of anti-synthetase)

Question 4

Systemic sclerosis, diffuse

Answer 4

Anti-Scl70 (= anti-DNA topoisomerase)

Question 5

Systemic sclerosis, esp with renal crisis

Answer 5

Anti-RNA polymerase (anti-U3 RNP)

Question 6

Mixed connective tissue disease

Answer 6

Anti-U1 RNP (anti-RNP not otherwise specified)

Question 7

Anti-Smith (anti-Sm)

Anti-double-stranded DNA (anti-dsDNA)

Answer 7

lupus

Question 8

Anti-nuclear (ANA)

Answer 8

Lupus and many other rheumatic diseases

Question 9

Sjogren syndrome, neonatal lupus, subcutaneous lupus

Answer 9

Anti-SSA (= anti-Ro) and Anti-SSB = (anti-La)

Question 10

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg Strauss)

Answer 10

Anti-myeloperoxidase

(= perinuclear anti-neutrophil cytoplasmic, P-ANCA) Microscopic

Question 11

Anti-proteinase-3 (= diffuse cytoplasmic

anti-neutrophil cytoplasmic, C-ANCA)

Answer 11

Granulomatosis with polyangiitis (Wegener’s)