Antibodies

Question 1

SLE

Answer 1

ANA, anti-dsDNA, anti-Smith

Question 2

Anti-ScL 70

Answer 2

Diffuse scleroderma (aka anti-topoisomerase antibodies)

Question 3

Anti-centromere antibodies

Answer 3

CREST syndrome (limited scleroderma)

Question 4

Anti-Ro, anti-La

Answer 4

Sjrogen’s

Question 5

c-ANCA (anti-Pr3)

Answer 5

Granulomatosis with polyangiitis

Question 6

p-ANCA (anti-mpo)

Answer 6

Eosinophilic granulomatosis with polyangiitis

Question 7

Anti-smooth muscle antibody

Answer 7

Autoimmune hepatitis type 1

Question 8

Anti-LKM1

Answer 8

Autoimmune hepatitis type 2

Question 9

Anti-mitochondrial antibodies

Answer 9

Primary biliary cholangitis

Question 10

Anti-Jo

Answer 10

Polymyositis

Question 11

Anti-Hu

Answer 11

Paraneoplastic neurological conditions -> encephalitis, associated with small cell lung cancer

Question 12

Anti-TPO and anti-thyroglobulin

Answer 12

Hashimoto’s

Question 13

Anti-TSH receptor and and anti-TPO

Answer 13

Graves’

Question 14

Anti-histone

Answer 14

Drug induced lupus

Question 15

anti-IgG4

Answer 15

autoimmune pancreatitis

Question 16

Anti-Ro

Answer 16

Seen in SLE, associated with complete heart block in babies of pregnant mums