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Immunoserology > Antibodies > Flashcards

Antibodies Flashcards

1
Q

Other term for antibodies

A

Immunoglobulins

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2
Q

End stage reaction of Humoral Immune Response

A

Antibody production

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3
Q

Type of immune response wherein antibody production occurs

A

Humoral Immune Response

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4
Q

Same with antibody classes; Lies on the heavy chain structure of the antibody

A

Isotype

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5
Q

Represents the genetically determined differences in the antibodies between individuals specifically in the amino acid sequence in the constant region

A

Allotype

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6
Q

Pertains to the variable region of the antibody

A

Idiotype

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7
Q

Recognizes different specific epitope present

A

Idiotype

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8
Q

Heavy Chain’s site of synthesis

A

Chromosome 14

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9
Q

Kappa Light Chain’s site of synthesis

A

Chromosome 2

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10
Q

Lambda Light Chain’s site of synthesis

A

Chromosome 22

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11
Q

Found between CH1
and CH2 – flexible region of the
antibody so that it can squeeze through the tissues

A

Hinge Region

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12
Q

A glycoprotein that is responsible for linking or bridging monomers together; Found in antibodies consist of 2 or more monomers

A

J Chain (Joining chain)

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13
Q

Two terminal regions of Immunoglobulins

A
  1. Carboxyterminal
  2. Aminoterminal
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14
Q

This bond holds light and heavy chains together

A

Covalent disulfide bonds

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15
Q

This links heavy chains together

A

Disulfide linkages

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16
Q

Four polypeptide chains of antibody

A
  1. 2 identical light chains
  2. 2 identical heavy chains
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17
Q

This terminal region dictates the allotype

A

Carboxyterminal

18
Q

This is where the crystallizable fragment (Fc) is located (constant region)

A

Carboxyterminal

19
Q

This terminal region determines the idiotype; variable region is located

A

Aminoterminal

20
Q

This specifically binds to the epitope of the antigen

A

Hypervariable portion of the variable region

21
Q

Varying antibody specificity

A

Aminoterminal

22
Q

Treatment with PAPAIN will produce which fragments?

A

1 Fc fragment
2 Fab fragment

23
Q

Fc fragment when treated with papain are involved in the following Ig biologic function:

A

▪ Involve in Complement Fixation
▪ Placental transfer of antibodies
▪ Binding site for cells

24
Q

What happens to 2 Fab fragments when antibody is treated with Papain?

A

Fab fragments cannot agglutinate/precipitate but still able of antigen binding.

25
Q

Treatment with Pepsin will produce which fragments?

A

2 Fab fragments

26
Q

What happens to Fc fragments when antibody is treated with Pepsin?

A

The Fc fragment is digested

27
Q

True or False:

In pepsin treatment of antibody, The two Fab fragments has two antigen combining sites (Bivalent), therefore, it is capable of antigen binding, precipitation and agglutination.

A

True

28
Q

How many domains of immunoglobulin are there?

A

Five domains

29
Q

What are the domains of immunoglobulins

A
  1. Variable region
  2. CH2
  3. CH3
  4. CL
  5. Hinge Region
30
Q

In domains of immunoglobulin, which domain is Responsible for the specificity of the antibody?

A

Variable region

31
Q

In domains of immunoglobulin, which domain binds with complement?

A

Constant Heavy Chain 2 (CH2)

32
Q

What antibodies are involved in the activation of Classical Pathway?

A

IgG and IgM

33
Q

In domains of immunoglobulin, which domain responsible for Cytotropic reaction?

A

Constant Heavy Chain 3 (CH3)

34
Q

This domain connects with receptors on cell membrane

A

Constant Heavy Chain 3 (CH3)

35
Q

This domain is either Kappa or Lambda

A

Constant Light Chain

36
Q

Percentage of Kappa Antibody Light chain

A

65%

37
Q

Percentage of Lambda Antibody Light chain

A

35%

38
Q

This domain is found between the CH1 and CH2 type of
antibody

A

Hinge Region

39
Q

Which complement protein does CH2 bind?

A

C1 specifically C1q

40
Q

The domain where Fab portion is located – the binding site of the
epitope of antigens

A

Variable region

41
Q

Why is flexibility important for Antibody?

A

It enables them to squeeze through or penetrate to the membrane

42
Q

Which amino acid is attributed to the flexibility of the antibody?

A

Proline

Immunoserology (4 decks)

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